消癥杀胚方联合米非司酮与甲氨蝶呤治疗输卵管妊娠的临床研究  

Clinical study on Xiaozheng killing embryo formula combined with mifepristone and methotrexate in the treatment of tubal pregnancy

作　　者：张晓玲[1] 张冬梅[1] 纪琼琼 ZHANG Xiaoling;ZHANG Dongmei;JI Qiongqiong(Department of Gynecology,Suining Traditional Chinese Medicine Hospital,Xuzhou,Jiangsu,221000,China)

机构地区：[1]睢宁县中医院妇科,江苏徐州221000

出　　处：《当代医学》2023年第21期18-21,共4页Contemporary Medicine

摘　　要：目的探讨消癥杀胚方联合米非司酮与甲氨蝶呤治疗输卵管妊娠的临床疗效。方法选取2020年1月至2021年12月本院收治的70例输卵管妊娠患者作为研究对象,采用随机数字表法分为两组,每组35例。对照组采用米非司酮联合甲氨蝶呤治疗,观察组在对照组基础上联合消癥杀胚方治疗,比较两组临床疗效、不同时间血清β-人绒毛膜促性腺激素(β-HCG)水平、症状消失时间及不良反应发生率。结果观察组治疗总有效率为97.14%,高于对照组的77.14%,差异有统计学意义(P<0.05)。两组血清β-HCG水平组间、时间、交互比较差异有统计学意义(P<0.05)。组内比较:两组治疗后各时间点血清β-HCG水平均低于前一时间点,差异有统计学意义(P<0.05)。组间比较:治疗前,两组血清β-HCG水平比较差异无统计学意义;治疗后第4、7、14、21天,观察组血清β-HCG水平均低于对照组,差异有统计学意义(P<0.05)。观察组腹痛消失时间、阴道流血停止时间、附件包块消失及β-HCG降至正常时间均短于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较差异无统计学意义。结论消癥杀胚方联合米非司酮与甲氨蝶呤治疗输卵管妊娠效果理想,可提高保守治疗成功率,降低血清β-HCG水平,缩小异位妊娠包块,且安全性较高,具有临床推广价值。Objective To explore the clinical efficacy of Xiaozheng killing embryo formula combined with mifepristone and methotrexate in the treatment of tubal pregnancy.Methods 70 patients with tubal pregnancy admitted to our hospital from January 2020 to December 2021 were selected as the research subjects,they were divided into the two groups according to the random number table method,with 35 cases in each group.The control group was treated with mifepristone combined with methotrexate,while the observation group was treated with Xiaozheng killing embryo formula on the basis of the control group,the clinical efficacy and serum levels ofβ-human chorionic gonadotropin(β-HCG)at different times,the symptom disappearance time,and the incidence of adverse reactions were compared between the two groups.Results The total effective rate in the observation group was 97.14%,which was higher than 77.14%in the control group,and the difference was statistically significant(P<0.05).There were significant differences in the level of serumβ-HCG between the two groups of group,time points,interaction(P<0.05).Comparison within the group:the serumβ-HCG level of the two groups were lower than that of the previous time point after treatment,and the differences were statistically significant(P<0.05).Comparison between groups:before treatment,there was no significant difference in serum the levels ofβ-HCG between the two groups;on the 4th,7th,14th,and 21st after treatment,the serum levels ofβ-HCG in the observation group were lower than that in the control group,and the differences were statistically significant(P<0.05).The disappearance time of abdominal pain,the stop time of vaginal bleeding,the disappearance time of accessory mass and the conversion time ofβ-HCG dropped to normal time in the observation group were shorter than those in the control group,and the differences were statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups.Conclusion Xi

关 键 词：消癥杀胚方 米非司酮 甲氨蝶呤 输卵管妊娠 

分 类 号：R714.221[医药卫生—妇产科学]