肺结核并艾滋病感染患者抗结核治疗依从性差的原因及影响因素分析  

Analysis of the causes and influencing factors of poor compliance of anti-tuberculosis treatment in patients with tuberculosis and acquired immune deficiency syndrome infection

作　　者：张磊 陈娜[2] ZHANG Lei;CHEN Na(Chongqing Changshou District Public Health Service Center,Chongqing,401220,China;Chongqing Changshou District Center for Disease Control and Prevention,Chongqing,401220,China)

机构地区：[1]重庆市长寿区公共卫生服务中心,重庆401220 [2]重庆市长寿区疾病预防控制中心,重庆401220

出　　处：《当代医学》2023年第21期77-80,共4页Contemporary Medicine

摘　　要：目的分析肺结核(TB)并艾滋病(AIDS)感染患者抗TB治疗依从性差的原因及影响因素。方法选取2017年12月至2019年1月重庆市长寿区公共卫生服务中心及重庆市长寿区疾病预防控制中心收治的64例肺TB并AIDS感染患者作为研究对象,采用自制肺TB并AIDS患者抗TB治疗依从性调查表进行调查,分析患者抗TB治疗依从性、依从性差的原因,采用单因素、多因素Logistic回归分析治疗依从性差的影响因素。结果64例患者中,抗TB治疗依从性良好35例,较差29例,治疗依从良好率为54.69%。依从性良好患者与依从性较差患者经济情况、抗TB知晓程度、药物不良反应、文化程度、婚姻情况比较差异有统计学意义(P<0.05)。多因素Loggistic回归分析结果显示,抗TB知晓程度低、有药物不良反应是抗TB治疗依从性差的独立危险因素(OR>1,P<0.05)。结论肺TB并AIDS感染患者普遍存在抗TB治疗依从性较差现象,其中抗TB知晓程度、药物不良反应为降低其用药依从性的主要因素。Objective To analyze the causes and influencing factors of poor compliance of anti-tuberculosis(TB)treatment in patients with pulmonary TB and acquired immune deficiency syndrome infection(AIDS)infection.Methods 64 patients with pulmonary TB and AIDS infection admitted to Chongqing Changshou District Public Health Service Center and Chongqing Changshou District Center for Disease Control and Prevention from December 2017 to January 2019 were selected as the research subjects,the self-made questionnaire on anti-TB treatment compliance of patients with pulmonary TB and AIDS was used to investigate,the patients'anti-TB treatment compliance and the reasons for poor compliance were analyzed,univariate and multivariate Logistic regression were used to analyze the influencing factors of poor treatment compliance.Results Among the 64 patients,35 cases had good anti-TB treatment compliance,29 cases had poor compliance,and the good compliance rate was 54.69%.There were significant differences in economic status,anti-TB awareness,adverse drug reaction,educational level,marital status between patients with good compliance and poor compliance(P<0.05).Multivariate Logistic regression analysis showed that low awareness of anti-TB and adverse drug reactions were independent risk factors for poor compliance with anti-TB treatment(OR>1,P<0.05).Conclusion Poor anti-TB treatment compliance is common in patients with pulmonary TB and AIDS infection,among which the awareness of anti-TB and adverse drug reactions are the main factors that reduce the medication compliance.

关 键 词：肺结核 艾滋病 抗结核 影响因素 独立危险因素 治疗依从性 

分 类 号：R521[医药卫生—内科学] R512.91[医药卫生—临床医学]