甘精胰岛素联合阿卡波糖治疗老年糖尿病的临床效果  

Clinical Effect of Insulin Glargine Combined with Acarbose in the Treatment of Elderly Diabetes

作　　者：苗曼悌[1] MIAO Mandi(Department of Geriatrics,Affiliated Hospital of Jiangsu University,Zhenjiang 212001,China)

机构地区：[1]江苏大学附属医院老年医学科,江苏镇江212001

出　　处：《中国医药指南》2023年第32期40-42,共3页Guide of China Medicine

摘　　要：目的探究甘精胰岛素联合阿卡波糖对老年糖尿病的治疗效果。方法选取江苏大学附属医院在2021年3月至2023年5月间收取120例老年糖尿病患者,分为两组,观察组60例,实施甘精胰岛素联合阿卡波糖疗法,对照组60例,采用单纯阿卡波糖治疗。对比两组的治疗有效性、血糖指标、不良反应、肠道激素水平、生活质量变化情况。结果治疗总有效性,观察组(93.33%)高于对照组(75%)(P<0.05)。血糖指标,治疗前两组对比无差别(P>0.05);治疗后两组均改善,且观察组均低于对照组(均P<0.05)。不良反应率,观察组(10%)低于对照组(23.33%)(P<0.05)。肠道激素水平,两组治疗前对比无差别(P>0.05);治疗后观察组血清抑胃肽比对照组低,空腹C肽、胰升血糖素样肽-1均高于对照组(均P<0.05)。生活质量评分,治疗前,两组对比无差别(P>0.05);治疗后,两组均改善且观察组各项评分均高于对照组(均P<0.05)。结论针对老年糖尿病患者,应用两种药物联合治疗的效果显著,能够提高治疗有效性,改善血糖指标及肠道激素水平,减少不良反应,提高生活质量。Objective To explore the therapeutic effect of insulin glargine combined with acarbose on senile diabetes.Methods 120 elderly patients with diabetes were selected from the Affiliated Hospital of Jiangsu University from March 2021 to May 2023,and were divided into two groups:the observation group(60 cases)was treated with insulin glargine combined with acarbose,and the control group(60 cases)was treated with acarbose alone.Compare the treatment effectiveness,blood glucose indicators,adverse reactions,intestinal hormone levels,and changes in quality of life between the two groups.Results In terms of overall treatment effectiveness,the observation group(93.33%)was higher than the control group(75%)(P<0.05).In terms of changes in blood glucose indicators,there was no difference between the two groups before treatment(P>0.05);After treatment,both groups improved,and the observation group was lower than the control group(both P<0.05).In terms of adverse reaction rate,the observation group(10%)was lower than the control group(23.33%)(P<0.05).In terms of gut hormone levels,there was no difference between the two groups before treatment(P>0.05);After treatment,the serum levels of gastric inhibitory peptide in the observation group were lower than those in the control group,while fasting C-peptide and glucagon-like peptide-1 were higher than those in the control group(all P<0.05).In terms of quality of life score,there was no difference between the two groups before treatment(P>0.05);After treatment,both groups improved and the observation group had higher scores than the control group(all P<0.05).Conclusions For the elderly patients with diabetes,the combined treatment of two drugs has a significant effect,which can improve the effectiveness of treatment,improve blood glucose indicators and intestinal hormone levels,reduce adverse reactions,and improve the quality of life.

关 键 词：老年糖尿病 甘精胰岛素 阿卡波糖 临床效果 

分 类 号：R587.1[医药卫生—内分泌]