基于黄酮醇的新型荧光探针的合成及应用研究  

Synthesis and application of novel fluorescent probes based on flavonol

作　　者：曾碧涛[1] 钟学芳 赵志刚[2] 石治川[2] ZENG Bi-tao;ZHONG Xue-fang;ZHAO Zhi-gang;SHI Zhi-chuan(Yibin Vocational&Technical College,Yibin 644003,China;College of Chemistry&Environment,Southwest Minzu University,Chengdu 610225,China)

机构地区：[1]宜宾职业技术学院,四川宜宾644003 [2]西南民族大学化学与环境学院,四川成都610225

出　　处：《现代化工》2023年第10期251-256,共6页Modern Chemical Industry

基　　金：宜宾职业技术学院院级重点科研项目(22ZRZD-07)。

摘　　要：以末端氯甲酸烯丙酯作为识别位点,3-羟基黄酮衍生物作为荧光团,通过特定的钯触发的裂解过程设计并合成了一种有较大红移的新型Pd^(2+)荧光探针(ZRC)。利用紫外-可见吸收光谱和荧光发射光谱研究了探针ZRC对Pd^(2+)的识别效果,结果表明,探针ZRC在温和条件下对溶液中的Pd^(2+)具有快速响应、高选择性和高灵敏度,检测限低至3.2 nmol/L。此外,探针ZRC还成功应用于斑马鱼体和实际液体样品中的Pd^(2+)检测。2-(5-Bromothiophen-2-yl)-4-oxy-4h-chroene-3-yl acrylate(ZRC),a novel Pd^(2+)fluorescent probe with significant red shift,is designed and synthesized through a specific palladium triggered cleavage process by using allyl chloroformate as the recognition site and 3-hydroxyflavonoid derivatives as the fluorescent group.The detection effect of ZRC probe on Pd^(2+)is studied by means of UV-Vis absorption spectra and fluorescence emission spectra.It is indicated that ZRC probe shows fast response,high selectivity and high sensitivity to Pd^(2+)in solution under mild conditions.The detection limit is as low as 3.2 nM.In addition,ZRC probe is also successfully applied to detect Pd^(2+)in zebrafish body and actual water samples.

关 键 词：荧光探针 钯离子 黄酮醇 烯丙基碳酸酯 反应型 

分 类 号：O656.9[理学—分析化学]