双歧杆菌四联活菌片联合乳果糖对儿童功能性便秘患者排便频次及肠道菌群的影响  

Effects of viable quadruplex Bifidobacterium tablets combined with lactulose on frequency of defecation and gut microbiota of children with functional constipation

作　　者：赵倩义 豆子莹 张骁[1] ZHAO Qianyi;DOU Ziying;ZHANG Xiao(Department of Pediatrics,the First Affiliated Hospital of He'nan University of Chinese Medicine,Zhengzhou,He'nan 450000,China;不详)

机构地区：[1]河南中医药大学第一附属医院儿科,河南郑州450000

出　　处：《中国微生态学杂志》2023年第10期1173-1177,共5页Chinese Journal of Microecology

基　　金：河南省中医药科学研究专项课题(20-21ZY2192)。

摘　　要：目的使用双歧杆菌四联活菌片联合乳果糖的治疗方案对儿童功能性便秘患者排便频次及肠道菌群的影响进行探究。方法通过随机数表法将选取的150例于2021年5月至2022年12月来我院进行便秘治疗的儿童分为观察组(75例)和对照组(75例),对照组患儿采用乳果糖进行治疗,观察组在对照组乳果糖治疗的基础上给予双歧杆菌四联活菌片,对两组患儿的临床疗效、排便频次、肠道菌群和不良反应以及复发率作对比。结果观察组和对照组患儿经治疗后的临床总有效率对比,对照组(86.67%)显著低于观察组(97.33%),差异有统计学意义(χ^(2)=4.438,P=0.035);治疗后两组患儿便秘频次和便秘困难程度评分与治疗前相比均有所降低,且对照组患儿的便秘频次和便秘困难程度评分降低幅度不及观察组显著(t=8.880,P<0.001);两组患儿经治疗后双歧杆菌数量均有增多,葡萄球菌、酵母菌、肠杆菌数量均有减少,且对照组患儿无论是双歧杆菌数量的增多情况或是葡萄球菌、酵母菌、肠杆菌数量的减少情况均不及观察组显著(t=7.823,P<0.001);观察组和对照组患儿中的不良反应发生率分别为9.33%和12.00%,差异无统计学意义(χ^(2)=0.280,P=0.597),复发率在观察组和对照组患儿中分别为2.67%和14.67%,差异有统计学意义(χ^(2)=5.390,P=0.020)。结论双歧杆菌四联活菌片联合乳果糖能够有效改善患儿的临床症状,增加患儿排便频次,平衡肠道菌群,提高患儿的生活质量。Objective To observe the effects of viable quadruplex Bifidobacterium tablets(VQBTs)combined with lactulose on the frequency of defecation and gut microbiota of children with functional constipation(FC).Methods A total of 150 children who came to our hospital for constipation treatment from May 2021 to December 2022 were randomized into the observation group(75 cases)or control group(75 cases).The children in the control group were treated with lactulose,and the observation group was given VQBTs and lactulose treatment.The clinical efficacy,frequency of defecation,gut microbiota,untoward reactions and recurrence rate were compared between groups.Results The control group(86.67%)had lower total clinical efficiency rate than observation group(97.33%),with a statistically difference(χ^(2)=4.438,P=0.035).After treatment,the frequency of defecation and difficulty degree of defecation in both groups decreased,and the decreases in frequency and difficulty degree of defecation in the control group was not obvious compared to the observation group(t=8.880,P<0.001).After treatment,the children in both groups had an increase in Bifidobacterial community,and decreases in Staphylococcus,Yeast and Enterobacterium communities;the increase in Bifidobacterial community and decreases in Staphylococcus,Yeast and Enterobacterium communities in the control group were less obvious than in the observation group(t=7.823,P<0.001).The incidence of untoward reactions in the observation group and the control group were 9.33%and 12.00%,respectively,with no statistically difference(χ^(2)=0.280,P=0.597).The recurrence rate in the observation group and control group was 2.67%and 14.67%,respectively,with a statistically difference(χ^(2)=5.390,P=0.020).Conclusion VQBTs combined with lactulose can effectively improve the clinical symptoms,increase the frequency of defecation,balance gut microbiota,and improve the quality of life of children with FC.

关 键 词：双歧杆菌四联活菌片 乳果糖 儿童功能性便秘 排便频次 肠道菌群 

分 类 号：R256.35[医药卫生—中医内科学]