Nasopharyngeal Local Transcriptional Profile upon SARS-CoV-2 Omicron BA.2.2 Breakthrough Infection  

作　　者：Yi Zhang Yang Zhou Yumeng Zhang Jiazhen Chen Jing Wu Peng Cui Shiyong Wang Yuanyuan Xu Zhongliang Shen Tao Xu Yang Li Jingwen Ai Ning Jiang Chao Qiu Wenhong Zhang 

机构地区：[1]Department of Infectious Diseases,Shanghai Key Laboratory of Infectious Diseases and Biosafety Emergency Response,National Medical Center for Infectious Diseases,Huashan Hospital,Shanghai Medical College,Fudan University,Shanghai 200040,China [2]School of Life Sciences,Fudan University,Shanghai 200438,China [3]Institutes of Biomedical Sciences,Fudan University,Shanghai 200032,China [4]National Clinical Research Center for Aging and Medicine,Huashan Hospital,Fudan University,Shanghai 200040,China [5]Shanghai Huashen Institute of Microbes and Infections,Shanghai 200052,China

出　　处：《Infectious Diseases & Immunity》2023年第4期186-191,共6页感染性疾病与免疫（英文）

基　　金：supported by the National Natural Science Foundation of China(Nos 92169212 and 82161138018);Shanghai Key Laboratory of Infectious Diseases and Biosafety Emergency Response(20dz2260100);Key Discipline Construction Plan fromShanghaiMunicipalHealth Commission(GWV-10.1-XK01);ShanghaiMunicipal Science and Technology Major Project(HS2021SHZX001).

摘　　要：The Omicron variants have continued to cause severe acute respiratory syndrome coronavirus 2 infections.To better understand the anti-viral effects of vaccination on host-virus interactions during the outbreak of BA.2.2 Omicron,we conducted RNA-seq transcriptome analysis on nasopharyngeal swabs from COVID-19 patients in Shanghai.This study was performed on selected cases from unvaccinated,fully vaccinated,and booster groups with the same founder virus infection background.We observed predominant immune cell chemotaxis and interleukin-1 production,as well as mucosal keratinization and epidermis development,in unvaccinated patients.In contrast,fully vaccinated subjects exhibited an obvious T-cell activation in the local immune response,whereas B-cell activation was higher in booster-vaccinated cases.In conclusion,our findings suggest that full or booster vaccination provides better adaptive immunity and relieve inflammation at the nasopharyngeal site,thereby reducing the risk of cytokine storm during breakthrough infection.

关 键 词：SARS-CoV-2 Local immune response TRANSCRIPTOME Inflammation 

分 类 号：R563.1[医药卫生—呼吸系统]