Lactate and protein lactylation:the ugly duckling of energy as the sculpture artist of proteins  

乳酸与蛋白质乳酸化修饰:能量代谢的“丑小鸭”变为“蛋白质雕塑艺术家”

作　　者：Linpeng Li Shanhu Sun Yi Wu Jianghuan Lu Jingcai He Keshi Chen Wai-Yee Chan Xingguo Liu 李林鹏;孙山虎;邬毅;陆江焕;何静彩;陈可实;陈伟仪;刘兴国(GMU-GIBH Joint School of Life Sciences,The Guangdong-Hong Kong-Macao Joint Laboratory for Cell Fate Regulation and Diseases,The Sixth Affiliated Hospital of Guangzhou Medical University,Qingyuan People’s Hospital,Key Laboratory of Biological Targeting Diagnosis,Therapy and Rehabilitation of Guangdong Higher Education Institutes,The Fifth Affiliated Hospital of Guangzhou Medical University,Guangzhou Medical University,CAS Key Laboratory of Regenerative Biology,Guangzhou Institutes of Biomedicine and Health,Chinese Academy of Sciences,Guangzhou 510000,China;Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine,China-New Zealand Joint Laboratory on Biomedicine and Health,CUHK-GIBH Joint Research Laboratory on Stem Cells and Regenerative Medicine,Guangzhou Institutes of Biomedicine and Health,University of Chinese Academy of Sciences,Chinese Academy of Sciences,Guangzhou 510000,China;Centre for Regenerative Medicine and Health,Hong Kong Institute of Science&Innovation,Chinese Academy of Sciences,Hong Kong,China;CUHK-GIBH Joint Research Laboratory on Stem Cells and Regenerative Medicine,CUHK-Jinan University Key Laboratory for Regenerative Medicine,Ministry of Education,School of Biomedical Sciences,Faculty of Medicine,The Chinese University of Hong Kong,Hong Kong,China)

机构地区：[1]GMU-GIBH Joint School of Life Sciences,The Guangdong-Hong Kong-Macao Joint Laboratory for Cell Fate Regulation and Diseases,The Sixth Affiliated Hospital of Guangzhou Medical University,Qingyuan People’s Hospital,Key Laboratory of Biological Targeting Diagnosis,Therapy and Rehabilitation of Guangdong Higher Education Institutes,The Fifth Affiliated Hospital of Guangzhou Medical University,Guangzhou Medical University,CAS Key Laboratory of Regenerative Biology,Guangzhou Institutes of Biomedicine and Health,Chinese Academy of Sciences,Guangzhou 510000,China [2]Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine,China-New Zealand Joint Laboratory on Biomedicine and Health,CUHK-GIBH Joint Research Laboratory on Stem Cells and Regenerative Medicine,Guangzhou Institutes of Biomedicine and Health,University of Chinese Academy of Sciences,Chinese Academy of Sciences,Guangzhou 510000,China [3]Centre for Regenerative Medicine and Health,Hong Kong Institute of Science&Innovation,Chinese Academy of Sciences,Hong Kong,China [4]CUHK-GIBH Joint Research Laboratory on Stem Cells and Regenerative Medicine,CUHK-Jinan University Key Laboratory for Regenerative Medicine,Ministry of Education,School of Biomedical Sciences,Faculty of Medicine,The Chinese University of Hong Kong,Hong Kong,China

出　　处：《Science Bulletin》2023年第21期2510-2514,共5页科学通报(英文版)

基　　金：supported by the National Natural Science Foundation of China(92157202,32025010,32241002,92254301,32261160376,31970709,32070729,32100619,32170747,32322022,32370782,32371007,32300608,and 32300620);the National Key Research and Development Program of China(2022YFA1103800,2022YFE0210100,and 2019YFA0904500);the Strategic Priority Research Program of the Chinese Academy of Sciences(CAS)(XDB0480000);the Key Research Program,CAS(ZDBS-ZRKJZ-TLC003);the International Cooperation Program,CAS(154144KYSB20200006);the CAS Project for Young Scientists in Basic Research(YSBR-075);the Guangdong Provincial Science and Technology Program(2023B1111050005,2023A1515030231,2022A1515110493,2020B1212060052,2021A1515012513,2021B1515020096,2022A1515012616,and 2022A1515110951);the Guangzhou Science and Technology Program(202102021037,202102020827,202102080066,and 202206060002);the Open Research Program of Key Laboratory of Regenerative Biology,CAS(KLRB202106,KLRB202107,and KLRB202203);the CAS Youth Innovation Promotion Association(Y2021097 and 2021355);NSFC/RGC Joint Grant Scheme(N_CUHK 428/22);the Open Research Funds from the Sixth Affiliated Hospital of Guangzhou Medical University,Qingyuan People’s Hospital(202301-203)。

摘　　要：Metabolites play important roles in numerous cell biology processes,such as cell proliferation,differentiation,stress response,and cell death[1].Recently,lactate and lactate-derived lysine residue lactylation(Kla)have emerged as newly discovered epigenetic modifications that play critical roles in various physiological and pathological processes.In the history of lactate research,we can categorize the studies into three mile stones(Fig.S1 online).

关 键 词：DEATH RESIDUE 能量代谢 

分 类 号：Q51[生物学—生物化学]