多组分一锅法合成2-氨基吡咯衍生物  

Multi-component one-pot synthesis of 2-aminopyrrole derivatives

作　　者：罗琴 肖强 陈丽 严胜骄[2] LUO Qin;XIAO Qiang;CHEN Li;YAN Sheng-jiao(Yunnan Medical Health College,Kunming 650033,Yunnan,China;School of Chemical Science and Technology,Yunnan University,Kunming 650091,Yunnan,China)

机构地区：[1]云南医药健康职业学院,云南昆明650033 [2]云南大学化学科学与工程学院,云南昆明650091

出　　处：《云南大学学报（自然科学版）》2023年第6期1314-1320,共7页Journal of Yunnan University(Natural Sciences Edition)

基　　金：云南省教育厅科学研究基金(2021J1362),国家自然科学基金(21662042).

摘　　要：建立了一种2-氨基吡咯衍生物的绿色合成方法,该方法以苯甲酰甲醛类化合物、1,1-烯二胺类化合物和2-羟基-1,4-萘醌为原料,在乙醇溶剂中,通过三组分一锅法串联反应合成8个多取代的2-氨基吡咯衍生物4a~4h,收率73%~78%.产物结构经1H NMR、13C NMR和HRMS表征.该方法具有环境友好、操作简单(过滤和洗涤,无柱色谱分离)、收率高、原料商品可得、目标化合物具有潜在生物活性等优点.In this paper,the green synthesis method was constructed for synthesis of 2-aminopyrrole derivatives,which through multi-component one-pot cascade reaction of the arylglyoxal monohydrates 1,1,1-endiamines(EDAMs)2,and 2-hydroxynaphthalene-1,4-dione 3 in ethanol.As a result,a series of 2-aminopyrrole derivatives 4a−4h have been synthesized with 73%−78%yields by this one-step reaction.All products were newly synthesized and fully characterized by 1H NMR,13C NMR and HRMS.This approach has several advantages such as the use of an environmentally-friendly solvent,simple and practical operation(with filtration and washing and no column chromatography separation),good yields,use of commercially available raw materials,diverse target compounds,and products with potential biological activity.

关 键 词：2-氨基吡咯 1 1-烯二胺 2-羟基-1 4-萘醌 多组分 绿色合成 一锅法 

分 类 号：O621.3[理学—有机化学]