基于专利引文网络的合成生物学领域主路径分析  

Main Path Analysis in the Field of Synthetic Biology Based on Patent Citation Network

作　　者：张婷[1] 徐东紫 陈娟[1] 杨潇逸 欧阳昭连[1] ZHANG Ting;XU Dongzi;CHEN Juan;YANG Xiaoyi;OUYANG Zhaolian(Institute of Medical Information,Chinese Academy of Medical Sciences,Beijing,China 100020)

机构地区：[1]中国医学科学院医学信息研究所,北京100020

出　　处：《中国药业》2023年第22期17-24,共8页China Pharmaceuticals

基　　金：国家自然科学基金[L1924064];中国医学科学院医学与健康科技创新工程项目[2021-I2M-1-056];北京协和医学院中央高校基本科研业务费项目[3332022041]

摘　　要：目的分析合成生物学领域的主路径。方法以“合成生物学”为主题词在Web of Science平台德温特专利数据库(DII)进行精准检索,得到专利数据集;构建专利引文网络,采用搜索路径连接数(SPLC)算法计算遍历权重,选择5种路径搜索方式,提取主路径,识别合成生物学技术创新热点。结果截至2023年6月5日,合成生物学领域共有专利申请432项,包含专利引文4987件。1992年至2021年,专利申请数量呈增长趋势,预计2025年和2030年专利申请数量将分别达到113项和216项;技术创新聚焦于基因合成及基因编辑相关研究。合成生物学领域局部后向主路径与全局主路径一致,识别出的专利数量最多,有14件,包含6条技术路线;局部前向主路径与全局关键路径主路径上的专利完全相同,仅技术轨迹有差异,识别出13件专利;局部前向主路径的技术路线最多,有12条。基于主路径分析,合成生物学领域技术创新主要聚焦于脂质体、样本处理方法、水凝胶、液滴网络等技术,高价值专利技术聚焦于生物打印、液滴封装、水凝胶网络等技术。结论主路径分析可识别技术发展轨迹及高价值专利,从情报学角度为合成生物学研究提供了信息支撑。Objective To analyze the main paths in the field of synthetic biology.Methods The patent data in the Derwent Innovation Index(DII)of the Web of Science were accurately searched with″synthetic biology″as the theme term to obtain a patent dataset.A patent citation network was constructed,the traversal weight was calculated by the search path link count(SPLC)algorithm,five path search methods were selected to extract the main path,and the hotspot of technical innovation of synthetic biology was identified.Results Up to June 5,2023,there were a total of 432 patent applications in the field of synthetic biology,including 4987 patent citations.The quantity of patent applications was increasing overally from 1992 to 2021,which was expected to reach 113 and 216 in 2025 and 2030 respectively.Technical innovation focused on researches related to gene synthesis and gene editing.The local backward main path of synthetic biology was consistent with the global main path,and the largest quantity of patents was identified(14 ones),including six technical routes.The patents on the local forward main path were identical to those on the global key-route main path,with only differences in technical trajectories,and 13 patents were identified.The technical routes on the local forward main path were the most(12 ones).Based on the main path analysis,technical innovation in the field of synthetic biology mainly focused on liposomes,sample processing methods,hydrogels,droplet networks and others,high-value patented techniques focused on bioprinting,droplet assembly,hydrogel networks and others.Conclusion Technique development trajectory and high-value patent can be identified based on the main path analysis,providing information support for the research of synthetic biology from the perspective of information science.

关 键 词：合成生物学 专利引文网络 主路径分析 搜索路径连接数算法(SPLC) 高价值专利 

分 类 号：R95[医药卫生—药学] G353.12[文化科学—情报学]