骨缺损修复生物材料诱导骨微环境中免疫应答机制的研究进展  

Research progress in mechanism of immune response induced by bone defect repair biomaterials in osteoimmune microenvironment

作　　者：刘潇 李明(指导) LIU Xiao;LI Ming(Department of Orthopedics,the Fourth Medical Center of the Chinese PLA General Hospital,National Clinical Research Center for Orthopedics Sports Medicine&Rehabilitation,Beijing 100853,China)

机构地区：[1]中国人民解放军总医院第四医学中心骨科医学部,国家骨科与运动康复临床医学研究中心,北京100853

出　　处：《中国免疫学杂志》2023年第11期2456-2460,F0004,共6页Chinese Journal of Immunology

基　　金：国家自然科学基金青年基金项目(82002317)。

摘　　要：骨缺损修复治疗是临床面临的难点问题,生物材料植入体内后引起局部骨微环境中免疫应答的变化是决定治疗成败的关键因素。然而当前生物材料普遍存在免疫调控缺陷问题,无法很好地诱导利于骨缺损修复的免疫微环境成为制约生物材料发展的瓶颈,限制了其广泛应用。因此,深入探索生物材料诱导骨微环境中的免疫应答机制十分必要。本文就主要参与骨修复生物材料介导免疫微环境中免疫细胞和细胞因子之间的作用机制研究进展进行综述。Treatment of bone defects remains a complicated clinical problem.Changes of immune response in local bone microenvironment following biomaterial implantation is key factor that determines success or not.However,there are many defects in immune regulation of biomaterials at present,failure to induce immune microenvironment that is conducive to bone defect repair has become a bottleneck restricting the development of biomaterials and limiting their widespread use.Therefore,it is necessary to deeply explore the changes of immune response induced by biomaterials in bone microenvironment.This article reviews the research progress of the interaction mechanism between immune cells and cytokines that are mainly involved in immune response mediated by bone repair biomaterials in the microenvironment.

关 键 词：骨缺损 生物材料 微环境 免疫应答 

分 类 号：R392.9[医药卫生—免疫学]