ERM蛋白在哺乳动物卵母细胞成熟和受精中的研究进展  

Research Progress of ERM Proteins in Mammalian Oocyte Maturation and Fertilization

作　　者：邵静 张颖 唐毓 许保增[1] SHAO Jing;ZHANG Ying;TANG Yu;XU Baozeng(Institute of Special Animal and Plant Sciences of Chinese Academy of Agricultural Sciences,Changchun 130112,China)

机构地区：[1]中国农业科学院特产研究所,长春130112

出　　处：《畜牧兽医学报》2023年第11期4477-4487,共11页ACTA VETERINARIA ET ZOOTECHNICA SINICA

基　　金：吉林省自然科学基金(YDZJ202201ZYTS450)。

摘　　要：受精是有性生殖的基本特征,也是个体发育的起点。卵母细胞的成熟状态是保障受精成功和胚胎发育的先决条件。卵母细胞在成熟和受精的过程里受到一系列分子机制细致精密的调控,在近年来发现的许多能调节哺乳动物卵母细胞成熟和受精的信号通路中,埃兹蛋白-根蛋白-膜突蛋白(ezrin-radixin-moesin,ERM)作为连接卵母细胞膜与细胞骨架的桥梁分子都直接或间接地介导了其中的多条通路,因此,ERM蛋白也成为研究这类生物学事件的焦点。本文综述了国内外关于ERM蛋白家族通过调节微绒毛的形成、极体的排出、卵母细胞-颗粒细胞间的信息交流以及精卵融合等细胞过程来参与卵母细胞成熟和受精过程的研究进展,以期为保障哺乳动物卵母细胞体外成熟和体外受精的成功率,提高雌性哺乳动物繁殖效率提供理论参考。Fertilization is the basic characteristic of sexual reproduction and forming the foundation of individual development.The maturation of oocytes is a prerequisite for successful fertilization and embryonic development.Oocytes are carefully regulated by a series of molecular mechanisms during maturation and fertilization.The ezrin-radixin-moesin(ERM)proteins act as a bridge between the oocyte membrane and the cytoskeleton,which directly or indirectly mediate many of the signaling pathways found in recent years that regulated mammalian oocyte maturation and fertilization.Therefore,ERM proteins have likewise become the focus of research on such biological events.This paper reviewed the research progress of the ERM protein family in the process of oocyte maturation and fertilization by regulating the formation of microvilli,polar-body extrusion,the exchange of information between oocytes and granulose cells,and sperm-egg fusion.These will provide a theoretical reference for ensuring the success rate of in vitro maturation and in vitro fertilization of mammalian oocytes and improving the reproductive efficiency of female mammals.

关 键 词：ERM蛋白 细胞膜-细胞骨架连接 减数分裂 受精 

分 类 号：S814[农业科学—畜牧学]