阿尔兹海默症动物实验的研究热点与趋势:基于WOS数据库的CiteSpace文献计量分析  

Research hot topics and trends of Alzheimer's disease animal experiments:CiteSpace bibliometric analysis based on the WOS database

作　　者：杨加辉 林萌 罗涛[2] 张先艳 陈来[1] 罗小泉[1] YANG Jiahui;LIN Meng;LUO Tao;ZHANG Xianyan;CHEN Lai;LUO Xiaoquan(Jiangxi University of Traditional Chinese Medicine,Nanchang 330004,China;the First Affiliated Hospital of Nanchang University,Nanchang 330006)

机构地区：[1]江西中医药大学,南昌330004 [2]南昌大学第一附属医院,南昌330006

出　　处：《中国实验动物学报》2023年第9期1156-1166,共11页Acta Laboratorium Animalis Scientia Sinica

基　　金：江西省科技基础条件平台(20212BCD46005);江西省中医药管理局科技计划项目(2022B1069);江西省卫生健康委科技计划项目(202310474)。

摘　　要：目的 本文采用文献计量学的方法揭示阿尔兹海默症动物实验的研究现状、热点与未来趋势并对其进行可视化分析,以帮助研究人员快速了解该领域的最新情况。方法 研究人员从WOSCC数据库中获取了2018~2022年关于AD动物实验领域的出版物。研究人员使用分析软件CiteSpace 6.2.R2(Advanced)对该领域相关出版物的相关信息进行分析。结果 本研究纳入2018~2022年4015篇文章,可发现论文年度发表量逐步增加。从文章数量来看,美国、加州大学系统、Saito T和《国际分子科学杂志》分别是发文量最多的国家、机构、作者、期刊。“阿尔兹海默症”出现频率最高,“焦虑”中心度数最高,内嗅皮层、神经元和突触的可塑性是目前研究的前沿与热点。结论 该领域集中于发病机制和治疗方法方面的研究,但研究多局限于机构与团体内部,缺乏国际间合作;未来应开展更加深入的研究,并加强国际合作以促进该领域的研究进展。Objective This paper uses bibliometric methods to reveal and visualize the current research status,hotspots and future trends of animal experiments on Alzheimer's disease,in order to help researchers quickly understand the latest situation in this field.MethodsWe obtained publications in the field of AD animal experiments from 2018 to 2022 from the Web of Science Core Collection database.We used the analysis software CiteSpace 6.2.R2(Advanced)to assess the general information and keywords of publications in this field.Results After analyzing 4015 articles from 2018 to 2022,we found that the annual publication volume of studies had gradually increased.In terms of the number of articles,the United States,the University of California System,Saito T,and the International Journal of Molecular Science are the country,institution,author,and journal with the largest number of articles,respectively."Alzheimer's disease"had the highest frequency of occurrence,and"anxiety"had the highest central degree.Conclusions This field focuses on research on pathogenesis and treatment methods,but research is mostly confined to institutions and organizations,and there is a lack of international cooperation;in the future,more in-depth research should be carried out and international cooperation should be strengthened in order to promote the progress of research in this field.

关 键 词：动物实验 阿尔兹海默症 文献计量分析 CITESPACE 可视化分析 

分 类 号：Q95-33[生物学—动物学]