复合刺激诱导多种呼吸系统疾病急性加重期动物模型的研究进展  

Research progress on animal models of acute exacerbation of various respiratory diseases induced by compound factors

作　　者：邱志广 邵雪洁 卢瑞龙 田燕歌[1,2,3] 任周新 QIU Zhguag;SHAO uejie;LU Ruilng;IAN Yange;REN Zhouxi(Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases Co-Constructed by Henan Province&Education Ministry of P.R.China,Henan University of Chinese Medicine,Zhengzhou 450046,China;Henan Key Laboratory of Chinese Medicine for Respiratory Disease,Zhengzhou 450046;Academy of Chinese Medicine Sciences,Henan University of Chinese Medicine,Zhengzhou 450046)

机构地区：[1]河南中医药大学呼吸疾病中医药防治省部共建协同创新中心,郑州450046 [2]河南省中医药防治呼吸病重点实验室,郑州450046 [3]河南中医药大学中医药科学院,郑州450046

出　　处：《中国实验动物学报》2023年第9期1177-1185,共9页Acta Laboratorium Animalis Scientia Sinica

基　　金：国家自然科学基金(82074406)。

摘　　要：基于临床实践的复合因素,如二次打击模式,在呼吸系统疾病急性加重模型的制作中取得了一定进展。本文汇总了复合因素构建的大鼠和小鼠肺纤维化、慢性阻塞性肺疾病和支气管哮喘急性加重模型,从动物品系选择、模型制备方法和主要的组织病理学变化等方面进行比较和分析,阐释每种模型的特征和适用范围,以期为研究者进一步改良和完善模型或合理选择模型提供参考。On the basis of the compound factors of clinical practice,some progress has been made in acute exacerbation models of respiratory diseases by the two-hit method.In this review,we summarize the current research on acute exacerbation models of pulmonary fibrosis,chronic obstructive pulmonary disease,and bronchial asthma established by compound factors.The characteristics and application scope of each model are compared and analyzed in terms of animal selection,model preparation method,and major histopathological changes,providing a reference for researchers to further improve and perfect the model or rationally select animal models.

关 键 词：肺纤维化 慢性阻塞性肺疾病 支气管哮喘 急性加重动物模型 复合因素 

分 类 号：Q95-33[生物学—动物学]