小型猪在中医动物模型中的应用研究进展  

Progress in the application of minipigs as animal models of Chinese medicine

作　　者：李子祥 邱华明 吴延军 赵海 吴曙光 LI Zixiang;QIU Huaming;WU Yanjun;ZHAO Hai;WU Shuguang(Laboratory Animal Research Institute,Guizhou University of Traditional Chinese Medicine,Guiyang 550025,China)

机构地区：[1]贵州中医药大学实验动物研究所,贵阳550025

出　　处：《中国实验动物学报》2023年第9期1186-1193,共8页Acta Laboratorium Animalis Scientia Sinica

基　　金：国家自然科学基金(82160957);贵州省科技计划项目(黔科合支撑[2021]一般148);2021年国家自然科学基金后补资金科研创新探索专项(2018YFL170810516);贵州中医药大学研究生教育创新计划自然科学项目(YCXZR2020008)。

摘　　要：中医动物模型是开展中医药研究的实验基础和必备工具。小型猪具有遗传特性稳定、体型小、易繁殖、性格温顺、易饲养、生理生化水平和疾病病理表现与人类相似等特点,是构建实验动物模型的理想选择,在医药领域具有广阔的应用前景及研究价值。目前已有学者利用小型猪构建了虚寒证、血瘀证、实热证、脾气虚证等单纯证候模型;动脉粥样硬化脾虚痰浊证和冠心病痰瘀互结证等中医病证结合模型,均取得较好成果。但目前小型猪在中医动物模型中的应用尚不广泛,值得进一步探索。Animal models of TCM are the experimental basis and necessary tools to conduct TCM research.Minipigs have stable genetic characteristics,a small size,easy breeding,docile nature,and similar physiology,biochemistry,and disease pathological manifestations to humans,which are ideal to establish experimental animal models and have broad application prospects and research value in the field of medicine.Researchers use small pigs to establish models of simple symptoms such as deficiency cold,blood stasis,actual heat,and spleen Qi deficiency.Models of atherosclerosis with spleen deficiency and phlegm turbidity and coronary heart disease with phlegm and phlegm stasis have achieved good result.However,the application of minipigs as TCM animal models is not widespread and worthy of further exploration.

关 键 词：中医证候 小型猪 动物模型 病证结合 应用研究 

分 类 号：Q95-33[生物学—动物学]