中缝背核5 羟色胺能神经环路在慢性痛及 焦虑共病中的研究进展  

Research progress of dorsal raphe nucleus serotonergic neural circuit in chronic pain and anxiety comorbidities

作　　者：崔玥 黄文烨 孟凡成 薛茜 钱正一 陈桢熹 黄芷桐 武胜昔 白占涛 徐晖 CUI Yue;HUANG Wenye;MENG Fancheng;XUE Qian;QIAN Zhengyi;CHEN Zhenxi;HUANG Zhitong;WU Shengxi;BAI Zhantao;XU Hui(School of Life Sciences&Research Center for Resource Peptide Drugs,Shaanxi Engineering&Technological Research Center for Conversation&Utilization of Regional Biological Resources,Yan'an University,Yan'an 716099,China;Department of Neurobiology,School of Basic Medical Sciences,Air Force Medical University,Xi'an 710032,China)

机构地区：[1]延安大学生命科学学院多肽资源药物研究中心,陕西省区域生物资源保育与利用工程技术研究中心,陕西延安716099 [2]空军军医大学基础医学院神经生物学教研室,陕西西安710032

出　　处：《空军军医大学学报》2023年第11期1109-1112,1117,共5页Journal of Air Force Medical University

基　　金：国家自然科学基金(82221001,32271056);空军军医大学科技基金计划项目(2022XC002)。

摘　　要：慢性痛患者常伴随情绪认知障碍共病,譬如焦虑症、抑郁症等神经精神疾病。目前认为中缝背核(DRN)的5羟色胺(5-HT)能系统参与缓解慢性痛与焦虑,其神经环路机制尚不清楚。DRN 5-HT能神经元能够与大脑的广泛区域形成神经环路连接,DRN 5-HT能系统还存在着结构和功能的异质性。本文将从神经环路机制的角度出发,就目前已明确参与调控慢性痛和焦虑样行为的DRN 5-HT能神经元和相关神经环路研究进展进行综述。Patients with chronic pain are often accompanied by comorbid emotional cognitive disorders,such as anxiety disorders,depression and other neuropsychiatric diseases.It is currently believed that 5-hydroxytryptamine(5-HT)in the dorsal raphe nucleus(DRN)is systematically involved in the relief of chronic pain and anxiety,but the mechanism of its neural circuits remains unclear.DRN 5-HTergic neurons are able to form neural circuit connections with a wide range of brain regions,and its systems also have structural and functional heterogeneity.From the perspective of neural circuit mechanism,this paper will review the current research progress of DRN 5-HTergic neurons and related neural circuits that have been clearly involved in regulating chronic pain and anxiety-like behaviors.

关 键 词：中缝背核 5羟色胺 慢性痛 焦虑 

分 类 号：R338[医药卫生—人体生理学]