基于“肠-肾”轴理论的肠道微生态影响慢性肾病发生发展的机制及干预治疗  

To Discuss the Mechanism and Intervention Treatment of Intestinal Microecology in the Development of Chronic Kidney Disease Based on the Theory of“Gut-Kidney Axis”

作　　者：朱金惠 王玲 陶金华 马振祥[1] 段金廒[3] 刘培[3] 江曙[3] ZHU Jin-hui;WANG Ling;TAO Jin-hua;MA Zhen-xiang;DUAN Jin-ao;LIU Pei;JIANG Shu(School of Public Health,Nantong University,Nantong 226001,China;School of Pharmacy,Nantong University,Nantong 226019,China;Collaborative Innovation Center of Chinese Medicine Resources,Nanjing University of Chinese Medicine,Nanjing 210023,China)

机构地区：[1]南通大学公共卫生学院,江苏南通226001 [2]南通大学药学院,江苏南通226019 [3]南京中医药大学中药资源协同创新研究中心,江苏南京210023

出　　处：《南京中医药大学学报》2023年第10期1054-1062,共9页Journal of Nanjing University of Traditional Chinese Medicine

基　　金：国家自然科学基金面上项目(81974518);江苏省高校自然科学基金面上项目(19KJB360019);江苏省大学生创新科研项目(202110304104Y);研究生创新科研项目(KYCX21_3132)。

摘　　要：慢性肾脏疾病(Chronic kidney disease,CKD)是指由各种原因引起的慢性肾脏结构和功能障碍,包括各种原发的、继发的肾小球肾炎、肾小管损伤和肾血管病变等。复杂的发病机制与特异性治疗方案的缺乏使慢性肾病成为威胁人类生命健康的重大疾病。基于“肠-肾”轴理论,肠道菌群研究的病因学说为慢性肾病发病机制提供了一个全新的视角。概述了肠道微生态在慢性肾病发生发展过程中所发挥的作用,以及阐述以肠道菌群为靶点,中医药或益生菌益生元作为干预途径治疗慢性肾病的研究现状。这些研究将为探索针对肠道微生态的慢性肾病临床治疗新策略,提供重要的理论依据。Chronic kidney disease(CKD)refers to chronic renal structure and dysfunction caused by various causes,including various primary and secondary glomerulonephritis,renal tubular injury and renal vascular lesions.The complex mechanisms and the lack of specific treatment make the disease become a major problem threatening human life and health.Based on the"gut-kidney axis"theory,etiology of intestinal flora studies provide a new perspective for the study of the mechanisms.In this review,we discuss the role of intestinal microecology in the CKD,summarize the research status of treating CKD with intestinal flora as target and traditional chinese medicine or prebiotics(probiotics)as intervention approaches.These studies provide an important theoretical basis for new treatment strategies of chronic kidney disease.

关 键 词：慢性肾病 肠道菌群 尿毒素 中医药 益生元(菌) 

分 类 号：R285.5[医药卫生—中药学]