胃溃疡中医证候动物模型研究进展  

Research progress on animal model establishment and evaluation of TCM syndromes of gastric ulcer

作　　者：王雯 侯雨君 王路 鄢香芸 李艳秋 孙路强[1] 陈帅[1] 石云舟 郑倩华[1] 李瑛[2] WANG Wen;HOU Yujun;WANG Lu;YAN Xiangyun;LI Yanqiu;SUN Luqiang;CHEN Shuai;SHI Yunzhou;ZHENG Qianhua;LI Ying(College of Acupuncture and Massage,Chengdu University of Traditional Chinese Medicine,Chengdu 610075,China;Graduate School,Chengdu University of Traditional Chinese Medicine,Chengdu 610075)

机构地区：[1]成都中医药大学针灸推拿学院,成都610075 [2]成都中医药大学研究生院,成都610075

出　　处：《中国实验动物学报》2023年第10期1351-1360,共10页Acta Laboratorium Animalis Scientia Sinica

基　　金：国家重点研发计划项目(2022YFC3500604)。

摘　　要：胃溃疡是一种常见的消化系统疾病,中医药治疗该病效果显著,但其治疗机制至今尚未明确。建立一套科学客观的胃溃疡中医证候动物模型及模型评价体系,对促进中医药在此领域的发展以及进一步的研究具有重大意义。笔者对近10年中医药治疗胃溃疡相关文献进行整理,总结和分析了胃溃疡中医证候动物模型的制作与评价方法,对肝胃不和证、脾胃湿热证、胃络瘀阻证、脾胃虚寒证、胃阴不足证、肝郁脾虚证等动物模型的制作方法进行总结,发现目前的胃溃疡动物模型存在中医辨证分型不够统一、造模思路与证型局限、造模方法标准不一、模型病证结合不紧密、模型评价体系不规范等问题,并提出模型改进意见,以期为此领域的研究提供参考。Gastric ulcer is a common digestive system disease.Traditional Chinese medicine(TCM)has a significant effect in treatment of this disease.However,its treatment mechanism is unclear.Establishing a scientific and objective animal model and model evaluation system is of great significance to promote development of TCM in this field.This article organizes the literature related to treatment of gastric ulcer by TCM in the past 10 years and summarizes method for establishing and evaluating animal models of TCM syndromes relating to gastric ulcer.The method were reviewed for liver and stomach disharmony syndrome,spleen and stomach dampness-heat syndrome,blood stasis in stomach syndrome,deficiency cold of spleen and stomach syndrome,stomach Yin deficiency syndrome,and liver depression and spleen deficiency syndrome.The current animal models of gastric ulcer had the following problems:the typing of TCM syndromes was not unified,the method and syndrome types of the models were limited,the standards of model establishment method were different,the combination of disease and syndrome of models was not close enough,and the model evaluation system was not standardized.Suggestions for model improvement are proposed to provide a reference for research in this field.

关 键 词：胃溃疡 中医证候 动物模型 评价方法 

分 类 号：Q95-33[生物学—动物学]