空腹血糖水平与早发血管衰老发生风险的关联性  

Association between fasting blood glucose level and the risk of early vascular aging

作　　者：刘芬芬 杨玉娇 袁熙 刘萍 滕若凌 丁怡[1] Liu Fenfen;Yang Yujiao;Yuan Xi;Liu Ping;Teng Ruoling;Ding Yi(Department of Geriatrics,the First People′s Hospital of Changzhou(the Third Affiliated Hospital of Soochow University),Changzhou 213000,China;BSc Mathematics with Management,University College London,London WC1E 6BT,UK)

机构地区：[1]常州市第一人民医院(苏州大学附属第三医院)老年医学科,常州213000 [2]伦敦大学学院,伦敦WC1E 6BT

出　　处：《中华内分泌代谢杂志》2023年第9期759-764,共6页Chinese Journal of Endocrinology and Metabolism

基　　金：2021年江苏省卫生健康委员会老年健康科研课题项目(LK202140)。

摘　　要：目的探讨空腹血糖水平与早发血管衰老(early vascular aging, EVA)发生风险的关联性。方法回顾性分析2020年1月至2021年3月常州市第一人民医院体检中心695名体检者的基本信息、既往病史及实验室检查等信息, 分析空腹血糖水平与EVA发生风险的关联性。结果共纳入健康体检者695名, 其中EVA患病者249例, 非EVA患者446名。EVA组和非EVA组相比, 年龄、性别、三酰甘油、高密度脂蛋白胆固醇(HDL-C)、空腹血糖、左侧肱-踝脉搏波传导速度(left brachial-ankle pulse wave velocity, L-baPWV)、右侧肱-踝脉搏波传导速度(right brachial-ankle pulse wave velocity, R-baPWV)、收缩压和舒张压, 组间差异有统计学意义(均P<0.01)。所有体检者按空腹血糖三等分分组(T1、T2、T3组), 随着空腹血糖水平的升高, 体重指数、总胆固醇、三酰甘油、HDL-C、低密度脂蛋白胆固醇、L-baPWV、R-baPWV、收缩压、舒张压及EVA指标, 在3组间差异均有统计学意义(均P<0.05)。单因素logistic回归分析显示, 年龄、性别、三酰甘油、HDL-C、收缩压、舒张压及空腹血糖水平与EVA的发生存在相关性(均P<0.05)。对于连续变量的空腹血糖, 在未校正、初步校正和充分校正协变量的回归方程中, 空腹血糖的升高均显著升高了EVA的风险, OR分别为2.249、2.580、2.413(均P<0.001)。与空腹血糖水平T1组相比较, T2组在未校正、初步校正和充分校正协变量后, EVA的风险分别为1.881、2.040、1.972(均P<0.01);T3组在未校正、初步校正和充分校正协变量后, EVA的风险分别为3.234、3.733、3.410(均P<0.001)。校正混杂因素后, 通过平滑曲线拟合发现空腹血糖水平与EVA的发生呈线性关系。结论空腹血糖升高可增加EVA发生的风险。Objective To investigate the association between fasting blood glucose levels and the risk of early vascular aging(EVA).Methods The basic information,medical history,and laboratory results of 695 individuals who underwent health check-up at the Physical Examination Center of the First People′s Hospital of Changzhou from January 2020 to March 2021 were retrospectively analyzed.Results A total of 695 healthy individuals were included in the study,among whom there were 249 cases of EVA and 446 cases of non-EVA.Compared to the non-EVA group,the EVA group showed significant differences in age,gender,triglycerides,high density lipoprotein-cholesterol(HDL-C),fasting blood glucose,left brachial-ankle pulse wave velocity(L-baPWV),right brachial-ankle pulse wave velocity(R-baPWV),systolic blood pressure,and diastolic blood pressure(all P<0.01).All participants were divided into three groups(T1,T2,T3)based on fasting blood glucose levels.As fasting blood glucose levels increased,body mass index,total cholesterol,triglycerides,HDL-C,low density lipoprotein-cholesterol,L-baPWV,R-baPWV,systolic blood pressure,diastolic blood pressure,and EVA indicators showed significant differences among the three groups(all P<0.05).Univariate logistic regression analysis showed that age,gender,triglycerides,HDL-C,systolic blood pressure,diastolic blood pressure,and fasting blood glucose levels were significantly associated with the occurrence of EVA(all P<0.05).For the continuous variable of fasting blood glucose,in the regression equations without correction,with preliminary correction,and with full correction of covariates,higher fasting blood glucose levels significantly increased the risk of EVA,with odds ratios(OR)of 2.249,2.580,and 2.413,respectively(all P<0.001).Compared to the T1 group,the risk of EVA in the T2 group,after no correction,preliminary correction,and full correction of covariates,was 1.881,2.040,and 1.972,respectively(all P<0.01).The risk of EVA in the T3 group,unadjusted,preliminary adjustment,and full adjustment of c

关 键 词：空腹血糖 早发血管衰老 动脉硬化 

分 类 号：R543[医药卫生—心血管疾病]