丙硫氧嘧啶致药物超敏反应综合征一例并文献复习  

Drug hypersensitivity syndrome induced by propylthiouracil: One case report and literature review

作　　者：王庆瑶 陈欣欣 沈琼[1] 臧欢欢 从相国[1] 俞岭 陈蕾[1] Wang Qingyao;Chen Xinxin;Shen Qiong;Zang Huanhuan;Cong Xiangguo;Yu Ling;Chen Lei(Department of Endocrinology,Suzhou Municipal Hospital Affiliated to Nanjing Medical University,Suzhou 215002,China)

机构地区：[1]南京医科大学附属苏州医院内分泌科,苏州215002

出　　处：《中华内分泌代谢杂志》2023年第9期804-808,共5页Chinese Journal of Endocrinology and Metabolism

摘　　要：本文报道1例38岁女性经丙硫氧嘧啶治疗约1个月后出现药物超敏反应综合征, 经阿达木单抗、糖皮质激素、丙种免疫球蛋白以及血浆置换等方案治疗后好转。丙硫氧嘧啶是引起药物超敏反应综合征的罕见药物, 同时在出院后随访过程中观察到该患者甲状腺自身抗体及甲状腺功能的快速变化。通过分析该患者病情演变并对相关文献进行复习, 可以提高临床对该类疾病的认识及诊治水平。This article reports a case of a 38-year-old female who developed drug hypersensitivity syndrome one month after receiving propylthiouracil.The patient showed improvement with adalimumab,corticosteroids,intravenous immunoglobulin,and plasma exchange.Propylthiouracil is a rare medication associated with drug hypersensitivity syndrome.Additionally,during the follow-up after discharge,rapid changes in thyroid autoantibodies and thyroid function were observed in this patient.By analyzing the progression of this case and reviewing literature,it aims to enhance clinical understanding and management.

关 键 词：自身免疫性甲状腺炎 丙硫氧嘧啶 药物超敏反应综合征 伴嗜酸性粒细胞增多和系统受累的药疹 阿达木单抗 

分 类 号：R969[医药卫生—药理学]