Omega-3脂肪酸联合物理方法降低老年股骨近端骨折患者术后深静脉血栓形成风险的研究  

Omega-3 fatty acids combined with physical methods to reduce the risk of postoperative deep vein thrombosis in elderly patients with proximal femoral fractures

作　　者：宋苗苗[1] 陈晓[1] 戚桂松 吴雪玲 王路[1] 郑新英 SONG Miao-miao;CHEN Xiao;QI Gui-song(Department of Orthopedics,Cangzhou Central Hospital,Cangzhou Hebei 061001,China)

机构地区：[1]沧州市中心医院骨科,河北沧州061001

出　　处：《临床和实验医学杂志》2023年第20期2193-2196,共4页Journal of Clinical and Experimental Medicine

基　　金：河北省卫健委重点研发指导项目(编号:20191161);沧州市重点研发计划指导项目(编号:213106106)。

摘　　要：目的探讨Omega-3脂肪酸联合物理方法降低老年股骨近端骨折(PFF)患者术后深静脉血栓形成(DVT)风险的研究。方法选择2020年9月至2021年9月沧州市中心医院就诊的老年PFF患者120例进行前瞻性研究,均接受手术治疗,按随机数字表法分为两组,各60例。对照组予以物理方法治疗,研究组在此基础上予以Omega-3脂肪酸治疗,连续给药2个月。比较两组凝血功能指标[血小板计数(PLT)、凝血酶原时间(PT),活化部分凝血活酶时间(APTT)]、细胞免疫功能(CD3^(+)、CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+))、术后DVT风险与术后并发症等情况。结果治疗前后,两组各项凝血功能指标比较,差异均无统计学意义(P>0.05)。治疗2个月后,两组CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)含量较治疗前升高,且研究组CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)含量分别为(69.9±6.3)%、(41.6±4.6)%、1.8±0.5,均分别高于对照组[(55.3±5.7)%、(35.4±4.2)%、1.4±0.5],差异均有统计学意义(P<0.05);两组治疗前后CD8^(+)含量比较,差异均无统计学意义(P>0.05)。研究组术后DVT发生率为5.0%,低于对照组(18.3%),差异有统计学意义(P<0.05)。研究组术后并发症总发生率为8.3%,低于对照组(18.3%),差异有统计学意义(P<0.05)。结论在老年PFF治疗中,给予Omega-3脂肪酸联合物理方法的疗效显著,有利于改善细胞免疫功能,降低术后DVT风险,值得推广。Objective To investigate the effect of Omega-3 fatty acids combined with physical methods on reducing the risk of postoperative deep vein thrombosis(DVT)in elderly patients with proximal femoral fracture(PFF).Methods A prospective study was conducted on 120 elderly patients with PFF who visited Cangzhou Central Hospital from September 2020 to September 2021.All of them received surgical treatment and were randomly divided into two groups according to the random number table,with 60 cases in each group.The control group was treated with physical therapy,while the study group was treated with Omega-3 fatty acid on the basis of this,and practiced administration for 2 months.The coagulation function indicators[platelet count(PLT),prothrombin time(PT),activated partial thromboplastin time(APTT)],cellular immune function(CD3^(+),CD4^(+),CD8^(+),CD4^(+)/CD8^(+)),DVT risk after treatment,and postoperative complications were compared between the two groups.Results Before and after treatment,there was no statistically significant difference in various coagulation function indicators between the two groups(P>0.05).After 2 months of treatment,the levels of CD3^(+),CD4^(+),and CD4^(+)/CD8^(+)in two groups were higher than those before treatment,and the levels of CD3^(+),CD4^(+),and CD4^(+)/CD8^(+)in the study group were(69.9±6.3)%,(41.6±4.6)%,and 1.8±0.5,respectively,which were higher than those in the control group[(55.3±5.7)%,(35.4±4.2)%,and 1.4±0.5],the differences were statistically significant(P<0.05).There was no statistically significant difference in CD8^(+)levels between the two groups before and after treatment(P>0.05).The total incidence of DVT risk after treatment in the study group was 5.0%,which was lower than that in the control group(18.3%),the difference was statistically significant(P<0.05).The total incidence of postoperative complications in the study group was 8.3%,which was lower than that in the control group(18.3%),the difference was statistically significant(P<0.05).Conclusion In the treatment o

关 键 词：老年人 股骨近端骨折 OMEGA-3脂肪酸 物理方法 深静脉血栓 

分 类 号：R687.3[医药卫生—骨科学]