MRE11A基因多态性与心肌梗死的相关性研究  

The association between polymorphisms of MRE11A gene and myocardial infarction

作　　者：金可可[1] 戈睿佗 张利勇 虞旭东 JIN Ke-ke;GE Rui-tuo;ZHANG Li-yong;YU Xu-dong(Yueqing People's Hospital Afiliated to Wenzhou Medical College,Leqing,Zhejiang 325600,China)

机构地区：[1]温州医科大学附属乐清市人民医院,浙江乐清325600

出　　处：《中国卫生检验杂志》2023年第21期2626-2629,2634,共5页Chinese Journal of Health Laboratory Technology

基　　金：浙江省温州市科技局项目(Y20090239)。

摘　　要：目的研究中国南方汉族人群中DNA损伤和修复因子基因多态性与心肌梗死发病风险的相关性。方法对207例经冠状动脉造影确诊心肌梗死患者和202例健康对照组的5个基因多态性进行检测,比较不同基因型和等位基因与心肌梗死患病风险的关系。结果在这5个与DNA损伤和修复密切相关的因子(减数分裂重组11同源物A、活性氧调节因子1、白介素-10、脆性组氨酸三联体基因和琥珀酰-戊二酸辅酶A转移酶)中,位于减数分裂重组11同源物A(MRE11A)基因的rs2155209多态性在心肌梗死组与对照组间差异有统计学意义,其等位基因和基因型的分布频率符合Hardy-Weinberg平衡(Х^(2)=0.255,P>0.05)。心肌梗死组rs2155209C等位基因频率高于对照组(24.9%vs 15.6%,P=0.02),logistic回归分析发现MRE11A rs2155209CC+CT基因型携带者患心肌梗死的风险高于TT基因型携带者(0R=2.01,95%CI:1.33~3.05,P=0.001),且这一关系独立于性别、年龄、吸烟、高血压、糖尿病及血清总胆固醇(total cholestero,TC)、低密度脂蛋白(lowdensity lipoprotein,LDL-C)水平等危险因素之外。没有证据表明其余SNPs与冠心病易感性相关。结论MRE11A基因rs2155209多态性可能是中国南方汉族人群心肌梗死发病的遗传危险因素之一。Objective This paper aims to investigate the association between the genetic polymorphisms of factors associated with DNA damage and repair and susceptibility to myocardial infarction(MI)in south Chinese Han population.Methods Five gene polymorphisms of 207 patients with myocardial infarction confirmed by coronary angiography and 202 healthy controls were detected to compare the relationship between different genotypes and alleles and the risk of myocardial infarction.ResultsAmong the five factors closely associated with DNA damage and repair(meiotic recombination 11 homolog A,reactive oxygen regulator 1,interleukin-10,fragile histidine triad gene,and Succinyl-CoA:glutarate-CoA transferase),the rs2155209 polymorphism in the meiosis recombination 11 homolog A(MRE11A)gene was different between the myocardial infarction group and the control group,with the differences statistically significant.The allel and genotype frequencies of MREllA gene were consistent with that predicted by Hardy-Weinberg equilibrium(Х^(2)=0.255,P>0.05).The rs2155209 C alleles in MI patients was signifi-cantly higher than that of the control group(24.9%vs 15.6%,P=0.02).Logistic regression analysis found that MRE11A rs2155209 CC+CT genotype carriers had a higher risk of myocardial infarction than TT genotype carriers(OR=2.01,95%CI:1.33-3.05,P=0.001).This association was independent of risk factors such as sex,age,smoking,high blood pressure,diabetes,and serum total cholesterol(TC)and low density lipoprotein(LDL-C)levels.There was no evidence that the remaining SNPs were associated with coronary heart disease susceptibility.Conclusion The rs2155209 polymorphisms in the MRE11A gene may contribute to an increased risk of MI among south Chinese Han population.

关 键 词：心肌梗死 减数分裂重组11同源物A 活性氧调节因子1 白介素-10 脆性组氨酸三联体基因 琥珀酰-戊二酸辅酶A转移酶 

分 类 号：R542.22[医药卫生—心血管疾病]