腹透滤出液中sICAM-1与腹膜透析患者腹膜功能的相关性分析  

Correlation between soluble intercellular adhesion molecule-1 in drained dialysate and peritoneal function in patients with peritoneal dialysis

作　　者：邱杰山 徐丽清 李霞[1] 暨利军 王燕翔 张婷玉 QIU Jie-shan;XU Li-qing;Li Xia;JI Li-jun;WANG Yan-xiang;ZHANG Ting-yu(Department of Nephrology,Xianju People's Hospital,Southeast District of Zhejiang Provincial People's Hospital,Zhejiang 317300,China)

机构地区：[1]仙居县人民医院浙江省人民医院浙东南院区肾内科,浙江317300

出　　处：《中国卫生检验杂志》2023年第21期2630-2634,共5页Chinese Journal of Health Laboratory Technology

基　　金：浙江省中医药科技计划项目(2023ZL793);仙居县人民医院青年创新人才支持计划(21yja02)。

摘　　要：目的探讨腹膜透析(PD)患者腹透滤出液中可溶性细胞间黏附分子-1(sICAM-1)水平与腹膜功能的相关性。方法纳入本中心行持续非卧床腹膜透析(CAPD)治疗的患者93例,收集患者一般临床资料及数据,行腹膜平衡试验(PET),计算PET4h腹透滤出液肌酐浓度与血浆肌酐浓度比值(D/P-Cr),4h腹透滤出液葡萄糖浓度与初始腹透液葡萄糖浓度比值(D/DO),Elisa法检测腹透滤出液中sICAM-1浓度。比较不同腹膜转运类型患者腹透滤出液中sICAM-1浓度的差异。通过两因素相关分析法,对腹透滤出液中sICAM-1浓度分别与D/P-Cr、D/DO及临床指标做相关性分析,通过多因素回归法分析腹透滤出液中sICAM-1浓度对PD患者腹膜功能的预测价值。结果根据PET,纳入研究的患者中高转运组17例、高平均转运组41例、低平均转运组26例,低转运组9例,比较发现,各组间sICAM-1浓度差异均有统计学意义,腹透滤出液中sICAM-1的浓度依次为高转运组>高平均转运组>低平均转运组>低转运组。两因素相关性分析显示,腹透滤出液中sICAM-1与D/P-Cr(r=0.674,P<0.001)、透析龄(r=0.279,P<0.05)及血清CRP(r=0.235,P<0.05)成正相关,与D/D0成负相关(T=-0.497,P<0.01)。多元线性回归分析发现,腹透滤出液中sICAM-1水平是D/P-Cr的预测因子。结论腹透滤出液中sICAM-1分子是D/P-Cr的预测因子,是反映PD患者腹膜功能的有效标记物。Objective This paper aims to investigate the correlation between the level of soluble intercellular adhesion molecule-1(sICAM-1)in drained dialysate and the peritoneal function in patients with peritoneal dialysis(PD).Methods A total of 93 patients who underwent continuous ambulatory peritoneal dialysis(CAPD)were included.The general clinical data were collected.Peritoneal equilibration test(PET)was performed to calculate the ratio of creatinine concentration in drained dialysate to plasma creatinine concentration(D/P-Cr)at 4 h and the ratio of glucose concentration in drained dialysate to initial peritoneal dialysis glucose concentration(D/DO)at 4 h.The level of sICAM-1 in drained dialysate was detected by a Elisa kit.The levels of sICAM-1 in drained dialysate of patients with different types of peritoneal transport were compared.The correlation between sICAM-1 with D/P-Cr,D/DO and clinical indexes was analyzed respectively.The value of sICAM-1 in predicting peritoneal function was investigated by multiple linear regression.Results Among the patients included in this study,there were 17 cases in high transport group,41 cases in high average transport group,26 cases in low average transport group and 9 cases in low transport group.There was statistical significance on the differences among the four groups in the levels of sICAM-1 in drained dialysate.The level of sICAM-1 showed a decreasing trend of high transport group>High average transport group>low average transport group>low transport group.Correlation analysis showed that sICAM-1 was positively correlated with D/P-Cr(r=0.674,P<0.001),PD duration(r=0.279,P<0.05)and serum CRP(r=0.235,P<0.05),which was negatively correlated with D/DO(r=-0.497,P<0.01).Multiple linear regression analysis showed that sICAM-1 level in drained dialysate was a predictor of D/P-Cr.Conclusion SICAM-1 level in drained dialysate is a predictor of D/P-Cr and can be used as an effective marker of peritoneal function in PD patients.

关 键 词：腹膜透析 可溶性细胞间黏附分子-1 腹膜功能 相关性 

分 类 号：R692.5[医药卫生—泌尿科学]