2021年深圳地区大学新生麻疹、风疹、流行性腮腺炎抗体水平调查  

Investigation on antibody levels of measles,rubella,and mumps among freshmen in Shenzhen in 2021

作　　者：阮嘉雯 洪烈城 胡鹏威[1] 于金太 俞慕华[1] 陈辉[1] 袁梦[1] RUAN Jia-wen;HONG Lie-cheng;HU Peng-wei;YU Jin-tai;YU Mu-hua;CHEN Hui;YUAN Meng(Shenzhen Nanshan District Center for Disease Control and Prevention,Shenzhen,Guangdong 518054,China;不详)

机构地区：[1]深圳市南山区疾病预防控制中心,广东深圳518054 [2]深圳市宝安区公共卫生服务中心 [3]中山大学公共卫生学院

出　　处：《现代预防医学》2023年第21期3999-4003,共5页Modern Preventive Medicine

基　　金：深圳市“医疗卫生三名工程”引进高层次医学团队项目(SZSM201803081);深圳市南山区卫健局病原生物学重点学科建设资助;深圳市南山区科技计划项目(NS102)。

摘　　要：目的了解深圳市南山区大学城大学新生麻疹、风疹、流行性腮腺炎Ig G抗体水平,为相关疾病防控措施的制定提供实验室依据。方法于2021年9月采集深圳市南山区大学城大学新生287份血清样品,用酶联免疫吸附试验定量检测麻疹、风疹、流行性腮腺炎Ig G抗体水平,比较不同特征大学新生各抗体水平差异。结果大学新生麻疹、风疹、流行性腮腺炎抗体总阳性率分别为83.27%、55.05%和82.92%,抗体几何平均浓度分别为500.43 m IU/ml、33.69 IU/ml和459.97 U/ml。不同年龄组新生麻疹、风疹抗体阳性率差异有统计学意义(χ^(2)麻疹=8.553,P<0.01;χ^(2)风疹=7.987,P<0.05);生源地不同的入学新生麻疹抗体保护率及麻疹、流行性腮腺炎抗体GMC差异存在统计学意义(χ^(2)麻疹=4.170,P<0.05;F麻疹=5.192,P<0.05;F流行性腮腺炎=4.621,P<0.05)。结论深圳市南山区大学城大学新生麻疹、风疹、流行性腮腺炎抗体水平较低。定期在大学生群体中开展抗体水平监测,有助于及时发现免疫薄弱群体;同时应对免疫薄弱人群及育龄期妇女开展免疫加强工作。Objective To investigate the IgG antibody levels of measles,rubella,and mumps among freshmen in Nanshan district,Shenzhen,and to provide laboratory basis for the prevention and control of related diseases.Methods In total 287 serum samples of freshmen in Nanshan district of Shenzhen city were collected in September 2021.The IgG antibody levels of measles,rubella,and mumps were quantitatively detected by enzyme-linked immunosorbent assay(Elisa).Results The total positive rates of measles,rubella,and mumps antibodies for freshmen were 83.27%,55.05%,and 82.92%,and the geometric mean concentrations of antibodies were 500.43 mIU/ml,33.69 IU/ml,and 459.97 U/ml,respectively.There were significant differences in the positive rates of measles and rubella antibodies among different age groups(χ^(2)measles=8.553,P<0.01;χ^(2)rubella=7.987,P<0.05).There were significant differences in measles antibody protection rate and measles and mumps antibody GMC among freshmen from different provinces(χ^(2) measles=4.170,P<0.05;F measles=5.192,P<0.05;F mumps=4.621,P<0.05).Conclusion The antibody levels of measles,rubella,and mumps among freshmen in Nanshan district of Shenzhen are low.Regular monitoring of antibody levels among college students is conducive to timely detection of immune weak groups.At the same time,immune strengthening efforts should be made targeting immune weak groups and women of childbearing age.

关 键 词：麻疹 风疹 流行性腮腺炎 抗体水平 

分 类 号：R186[医药卫生—流行病学] R511.1[医药卫生—公共卫生与预防医学] R511.2R512.1