去白红细胞储存时间与输血反应关系探讨  

Exploration of the relationship between the storage time of leukodepleted red blood cell and transfusion adverse reactions

作　　者：何流 刘建[2] 吴钢 王恩 易发艳 谭兴顺 朱诗玙 余锐 陆光辉 刘艳 翟梅 向清 刘平[2] 廖艳华[2] 付志珍 李茂林[2] 黄蓉[2] HE Liu;LIU Jian;WU Gang;WANG En;YI Fayan;TAN Xingshun;ZHU Shiyu;YU Rui;LU Guang-hui;LIU Yan;ZHAI Mei;XIANG Qing;LIU Ping;LIAO Yanhua;FU Zhizhen;LI Maolin;HUANG Rong(Key Laboratory of Transfusion Adverse Reactions,Chinese Academy of Medical Sciences,Institute of Blood Transfusion,Chinese A-cademy of Medical Sciences&Peking Union Medical College,Chengdu 610052,China;The People’s Hospital of Jianshi;The Central Hospital of Enshi Tujia and Miao Autonomous Prefecture;The People’s Hospital of Xuanen;Xianfeng Coun-ty People’s Hospital;Minda Hospital of Hubei Minzu University)

机构地区：[1]中国医学科学院北京协和医学院输血研究所、中国医学科学院输血不良反应研究重点实验室,四川成都610052 [2]建始县人民医院 [3]恩施州中心医院 [4]宣恩县人民医院 [5]咸丰县人民医院 [6]湖北民族大学附属民大医院

出　　处：《中国输血杂志》2023年第10期889-891,共3页Chinese Journal of Blood Transfusion

摘　　要：目的 通过统计分析4家医院输注去白细胞悬浮红细胞后输血反应的发生情况,探讨去白细胞悬浮红细胞储存时间与输血反应之间的关系。方法 通过电子病历管理系统查阅恩施州4家医院自2018—2022年相关病例输注去白细胞悬浮红细胞的采集和输血日期、产生的输血反应信息。结果 2018—2022年4家医院共输注去白红细胞69 761袋,发生输血反应166例,其中过敏反应93例,非溶血性发热反应63例,其他10例,输血反应总发生率0.24%。发生输血反应的去白细胞悬浮红细胞平均储存时间为(20.25±6.31)d,未发生输血反应的去白细胞悬浮红细胞平均储存时间为(19.88±5.50)d。将储存时间以7 d为界值进行分析,储存时间为15~21 d的输血反应发生率最低。以21 d为区分界值分为储存天数≤21 d和>21 d的2组,2组之间输血反应发生率比较无差异(P>0.05)。结论 去白细胞悬浮红细胞发生的输血反应以过敏反应为主,且输血反应发生率随去白细胞悬浮红细胞储存时间的延长呈现先下降后上升的趋势。储存时间≤21 d和>21 d的去白细胞悬浮红细胞的输血反应发生率无明显区别。Objective To explore the relationship between the storage time of leukodepleted red blood cells and transfusion adverse reactions by analyzing the occurrence of transfusion adverse reactions of patients after leukodepleted red blood cells transfusion from four hospitals.Methods By using the electronic medical record management system,the collection and transfusion dates of leukodepleted red blood cells from four hospitals in Enshi Prefecture from 2018 to 2022,as well as the information on transfusion adverse reactions,were retrieved.Results From 2018 to 2022,a total of 69761 bags of leukodepleted red blood cells were transfused in four hospitals,resulting in 166 cases of transfusion adverse reactions,among which 93 were allergic reactions,63 were non hemolytic febrile reactions,and 10 were others,with a total incidence rate of transfusion adverse reactions at 0.24%.The average storage time of leukodepleted red blood cells with and without transfusion adverse reactions was(20.25±6.31)and(19.88±5.50)days,respectively.With a storage time of 7 days as the threshold,the incidence of transfusion adverse reactions was the lowest for a storage time of 15~21 days.The incidence of transfusion adverse reactions of leukodepleted red blood cells in two groups(with storage days≤21 days and>21 days)was not statistically significant(P>0.05).Conclusion Allergic reactions were the main type of transfusion adverse reaction caused by leukodepleted red blood cells,and the incidence of transfusion adverse reactions decreased and then increased with the prolongation of the storage time of leukodepleted red blood cells.There was no significant difference in the incidence of transfusion adverse reactions with leukodepleted red blood cells stored for≤21 days and>21 days.

关 键 词：去白细胞悬浮红细胞 输血反应 储存时间 非溶血性发热反应 过敏反应 

分 类 号：R457.1[医药卫生—治疗学] R331.141[医药卫生—临床医学]