中药雷公藤多苷辅助治疗对糖尿病肾病患者糖脂代谢及肾功能的影响  

Effects of Adjuvant Therapy with Traditional Chinese Medicine Tripterygium Glycosides on Glucose-lipid Metabolism and Renal Function in Patients with Diabetic Nephropathy

作　　者：罗金国[1] 苏小惠[1] 刘霏[1] 蓝元隆[1] 蔡建盛 LUO Jinguo;SU Xiaohui;LIU Fei;LAN Yuanlong;CAI Jiansheng(Department of Nephrology,Zhangzhou Traditional Chinese Medicine Hospital Affiliated to Fujian University of Traditional Chinese Medicine,Zhangzhou,Fujian Province,363000 China)

机构地区：[1]福建中医药大学附属漳州市中医院肾内科,福建漳州363000

出　　处：《糖尿病新世界》2023年第17期8-11,共4页Diabetes New World Magazine

基　　金：福建中医药大学校管课题项目(XB2019020)。

摘　　要：目的 分析中药雷公藤多苷辅助治疗对糖尿病肾病患者糖脂代谢及肾功能的影响。方法 选取2020年6月-2021年6月福建中医药大学附属漳州市中医院收治的90例糖尿病肾病患者作为研究对象,按随机数表法分为观察组50例,采用中药雷公藤多苷联合厄贝沙坦片、二甲双胍治疗,和参考组40例,采用厄贝沙坦片、二甲双胍治疗。比较两组治疗前后血糖水平、血脂水平和肾功能指标改善情况。结果 治疗前两组血糖水平、血脂水平和肾功能指标水平相比,差异无统计学意义(P>0.05);治疗后两组血糖水平、血脂水平和肾功能指标水平均显著改善,且观察组改善情况均优于参考组,差异有统计学意义(P<0.05)。结论 中药雷公藤多苷辅助治疗糖尿病肾病更有利于促进糖脂代谢及肾功能指标改善。Objective To analyze the effects of adjuvant treatment with traditional Chinese medicine Tripterygium gly-cosides on glucose-lipid metabolism and renal function in patients with diabetic nephropathy.Methods A total of 90 diabetic nephropathy patients admitted to Zhangzhou Hospital of Traditional Chinese Medicine Affiliated to Fujian University of Chinese Medicine from June 2020 to June 2021 were selected as the study objects,and were divided into observation group(50 cases)by random number table method,treated with tripterygium glycosides combined with irbe-sartan tablets and metformin,and reference group(40 cases)treated with irbesartan tablets and metformin.The im-provement of blood glucose level,blood lipid level and renal function index before and after treatment were compared between the two groups.Results There was no statistically significant difference in blood glucose level,blood lipid level and renal function index between the two groups before treatment(P>0.05);after treatment,the levels of blood glucose,blood lipid and renal function indexes were significantly improved in both groups,and the improvement of in the observation group was better than that in the reference group,the difference was statistically significant(P<0.05).Conclusion The Chinese medicine Tripterygium wilfordii polyglycosides assisted treatment of diabetic nephropathy is more beneficial to promote glucose and lipid metabolism and improve renal function indexes.

关 键 词：中药 雷公藤多苷 辅助治疗 糖尿病肾病 糖脂代谢 肾功能 

分 类 号：R587.1[医药卫生—内分泌]