福州地区333例T2DM患者糖化血红蛋白和血糖、血脂的关系研究  

Relationship between Glycated Hemoglobin,Blood Glucose and Blood Lipid in 333 Patients with T2DM in Fuzhou Area

作　　者：周宜娟[1] 孙美珠 余孙兴[1] 王喆诤 ZHOU Yijuan;SUN Meizhu;YU Sunxing;WANG Zhezheng(Department of Clinical Laboratory,Health Management Center,the Second People's Hospital Affiliated to Fujian University of Traditional Chinese Medicine,Fuzhou,Fujian Province,350000 China)

机构地区：[1]福建中医药大学附属第二人民医院健康管理中心检验科,福建福州350000

出　　处：《糖尿病新世界》2023年第17期72-74,78,共4页Diabetes New World Magazine

摘　　要：目的 探讨福州地区的333例2型糖尿病(diabetes mellitus type 2, T2DM)患者糖化血红蛋白(hemoglobin A one c, HbA1c)水平及与血糖、血脂指标的相关性。方法 将2022年6月1~30日于福建中医药大学附属第二人民医院健康管理中心体检的333例T2DM患者作为研究对象,均接受HbA1c、血糖及血脂检测,根据HbA1c水平分组,HbA1c≥7.0%组与HbA1c<7.0%组,对比两组研究对象空腹血糖(fastingbloodglucose,FBG)、血脂水平,并以Pearson相关性分析HbA1c与空腹血糖、血脂的相关性。结果 HbA1c≥7.0%组的FPG、总胆固醇(total cholesterol, TC)、三酰甘油(triglyceride, TG)、低密度脂蛋白胆固醇(low density lipoprotein cholesterol,LDL-C)均显著高于HbA1c<7.0%,而高密度脂蛋白胆固醇(high density lipoprotein cholesterol,HDL-C)低于HbA1c<7.0%组,差异有统计学意义(P<0.05)。Pearson相关分析显示,HbA1c与HDL-C呈负相关(r=-0.530,P<0.05),与FBG、TC、TG、LDL-C呈正相关(r=0.543、0.712、0.607、0.822,P<0.05)。结论 对福州地区的T2DM患者测定,HbA1c水平与血糖、血脂密切相关,能为临床诊断和治疗提供重要参考,有着重要的临床意义。Objective To investigate the relationship between the levels of hemoglobin A one c(HbA1c)and blood glucose and lipid indexes in 333 patients with diabetes mellitus type 2(T2DM)in Fuzhou.Methods A total of 333 T2DM patients who came to the Health Management Center of the Second People's Hospital Affiliated to Fujian Uni-versity of Traditional Chinese Medicine for physical examination from June 1 to 30,2022 were enrolled as research ob-jects.All patients received HbA1c,blood glucose and blood lipid tests.According to HbA1c level,they were divided into HbA1c≥7.0%group and HbA1c<7.0%group.Fasting blood glucose(FBG)and blood lipid levels were compared between the two groups of subjects,and the correlation between HbA1c and fasting blood glucose and blood lipid were analyzed by Pearson correlation.Results The FPG,total cholesterol(TC),triglyceride(TG),and low density lipoprotein cholesterol(LDL-C)of the HbA1c≥7.0%group were significantly higher than those of the HbA1c<7.0%group,while high density lipoprotein cholesterol(HDL-C)was lower than that of the HbA1c<7.0%group,with a statistically sig-nificant difference(P<0.05).Pearson correlation analysis showed that HbA1c was negatively correlated with HDL-C(r=-0.530,P<0.05),and positively correlated with FBG,TC,TG,and LDL-C(r=0.543,0.712,0.607,0.822,P<0.05).Conclusion For T2DM patients in Fuzhou area,HbA1c level is closely related to blood glucose and blood lipid,which can provide an important reference for clinical diagnosis and treatment,and has important clinical significance.

关 键 词：福州地区 2型糖尿病 糖化血红蛋白 血糖 血脂 

分 类 号：R446.1[医药卫生—诊断学]