德谷门冬双胰岛素注射液治疗2型糖尿病临床效果及安全性探讨  

Discussion on the Clinical Effect and Safety of Insulin Degludec and Insulin Aspart Injection in the Treatment of Type 2 Diabetes Mellitus

作　　者：林生 谢平 陈予 LIN Sheng;XIE Ping;CHEN Yu(Department of Endocrinology,Changle District People's Hospital,Fuzhou,Fujian Province,350200 China)

机构地区：[1]福州市长乐区人民医院内分泌科,福建福州350200

出　　处：《糖尿病新世界》2023年第17期98-101,共4页Diabetes New World Magazine

摘　　要：目的 研究德谷门冬双胰岛素注射液治疗2型糖尿病的临床效果及安全性。方法 选取于2022年7月-2023年4月福州市长乐区人民医院收治的2型糖尿病患者98例为研究对象,采用随机抓阄法分为两组,每组49例。两组均联用常规降糖药物治疗,对照组采用甘精胰岛素注射液治疗,观察组采用德谷门冬双胰岛素注射液治疗。对比两组临床治疗效果、临床症状好转时间和胰岛素用量情况、糖代谢指标、胰岛素功能指标、不良反应发生情况、心血管不良事件发生情况。结果 观察组总有效率高于对照组,差异有统计学意义(P<0.05)。观察组尿酮体转阴时间、血糖达标时间、胰岛素用量均优于对照组,差异有统计学意义(P<0.05)。观察组空腹血糖、餐后2 h血糖、糖化血红蛋白均低于对照组,差异有统计学意义(P<0.05)。观察组胰岛β细胞功能指数高于对照组,胰岛素抵抗指数、空腹胰岛素低于对照组,差异有统计学意义(P<0.05)。两组恶心呕吐、倦怠乏力、低血糖总发生率比较,差异无统计学意义(P>0.05)。两组心绞痛、心力衰竭总发生率比较,差异无统计学意义(P>0.05)。结论 德谷门冬双胰岛素注射液治疗2型糖尿病临床效果显著优于甘精胰岛素注射液,但是治疗安全性无显著变化。Objective To study the clinical effect and safety of insulin degludec and insulin aspart injection in the treatment of type 2 diabetes mellitus.Methods A total of 98 patients with type 2 diabetes admitted to Fuzhou Changle District People's Hospital from July 2022 to April 2023 were selected as the study objects and divided into two groups with 49 cases in each group by random lottery method.Both groups were treated with conventional hypoglycemic drugs,the control group was treated with insulin glargine injection,and the observation group was treated with Degu asparton double insulin injection.The clinical therapeutic effect,time of improvement of clinical symptoms,insulin dosage,glucose metabolism index,insulin function index,occurrence of adverse reactions and cardiovascular adverse events were compared between the two groups.Results The total effective rate of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).The time of urine ketone body turning negative,blood glucose reaching standard and insulin dosage in observation group were better than those in control group,and the differences were statistically significant(P<0.05).Fasting plasma glucose,2-hour postprandial blood glucose and glycated hemoglobin in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).The function index of isletβcells in observation group was higher than that in control group,the insulin resistance index and fasting insulin was lower than that in control group,the dif-ference was statistically significant(P<0.05).There was no statistically significant difference in the total incidence of nausea,vomiting,fatigue and hypoglycemia between the two groups(P>0.05).There was no statistically significant dif-ference in the incidence of angina pectoris and heart failure between the two groups(P>0.05).Conclusion The clini-cal effect of Degu asparton injection was significantly better than insulin glargine i

关 键 词：2型糖尿病 德谷门冬双胰岛素注射液 不良反应 心血管不良事件 

分 类 号：R59[医药卫生—内科学]