糖尿病性慢性肾功能衰竭患者高通量血液透析治疗后Scr及ALB水平的变化研究  

Changes of Scr and ALB Levels in Patients with Diabetic Chronic Renal Failure after High-throughput Hemodialysis Treatment

作　　者：王晶[1] 程莉[1] 吴述洪 WANG Jing;CHENG Li;WU Shuhong(Department of Nephrology,NO.910 Hospital of Chinese People's Liberation Army Joint Logistic Support Force,Quanzhou,Fujian Province,362000 China)

机构地区：[1]中国人民解放军联勤保障部队第九一〇医院肾内科,福建泉州362000

出　　处：《糖尿病新世界》2023年第18期1-3,16,共4页Diabetes New World Magazine

摘　　要：目的分析在糖尿病性慢性肾功能衰竭患者血液透析中,选择采用高通量血液透析治疗方式对肾衰竭的治疗效果,并探析高通量血液透析前后患者肾功能情况和机体营养状况。方法回顾性分析2020年10月—2022年10月中国人民解放军联勤保障部队第九一〇医院肾内科收治的72例糖尿病性慢性肾功能衰竭患者的资料,患者均行高通量血液透析治疗。比较透析前后肾功能情况以及营养状况。结果高通量血液透析后患者肌酐、尿素氮、血尿酸、血尿素、甲状旁腺激素及血清β2-微球蛋白值均较透析前低,差异有统计学意义(P<0.05);透析后患者体内血红蛋白、总蛋白和血清白蛋白值较透析前高,差异有统计学意义(P<0.05)。高通量血液透析治疗后,出现1例感染、1例皮肤瘙痒和1例睡眠障碍,无高钾血症、代谢性酸中毒情况发生,并发症发生率为4.17%(3/72)。结论在糖尿病性慢性肾功能衰竭患者血液透析中选择高通量血液透析模式,可较好改善患者肾功能,提升机体营养状况,提升血液透析对疾病的治疗效果,并发症少,透析安全性高,是糖尿病性慢性肾功能衰竭患者血液透析首选透析方式。Objective To analyze the therapeutic effect of high-throughput hemodialysis on renal failure in patients with diabetic chronic renal failure.To investigate the renal function and nutritional status of patients before and after high-throughput hemodialysis.Methods The data of 72 patients with diabetic chronic renal failure admitted to the Department of Nephrology of the NO.910 Hospital of Chinese People's Liberation Army Joint Logistic Support Force from October 2020 to October 2022 were retrospectively analyzed.All patients were treated with high-flux hemodialysis.The renal function and nutritional status before and after dialysis were compared.Results The values of creatinine,urea nitrogen,blood uric acid,blood urea,parathyroid hormone and serumβ2-microglobulin in patients after high-flux hemodialysis were lower than those before dialysis,and the differences were statistically significant(P<0.05).The values of hemoglobin,total protein and serum albumin in patients after dialysis were higher than those before dialysis,and the differences were statistically significant(P<0.05).After high-flux hemodialysis treatment,there were 1 case of infection,1 case of skin itching and 1 case of sleep disorder,no hyperkalemia and metabolic acidosis occurred,and the incidence of complications was 4.17%(3/72).Conclusion Choosing the high-throughput hemodialysis mode in the hemodialysis of patients with diabetic chronic renal failure can better improve patients'kidney function,improve the nutritional status of the body,and enhance the treatment effect of hemodialysis on the disease,with fewer complications and high dialysis safety,which is the first choice for hemodialysis of patients with diabetic chronic renal failure.

关 键 词：糖尿病性慢性肾功能衰竭 高通量血液透析 血肌酐 白蛋白 

分 类 号：R4[医药卫生—临床医学]