诺雷德联合激素替代疗法治疗子宫内膜异位症效果及对患者卵巢功能和妊娠影响  

Effect of zoladex combined with hormone replacement therapy for treating patients with endometriosis and its influence on the levels of estrogen and anti-Mullerian hormone and the pregnancy

作　　者：徐兰 丁森林[1] XU Lan;DING Senlin(Guang'an People's Hospital,Guang'an,Sichuan Province,638000)

机构地区：[1]四川省广安市人民医院,638000

出　　处：《中国计划生育学杂志》2023年第11期2568-2571,共4页Chinese Journal of Family Planning

摘　　要：目的:探究诺雷德联合激素替代疗法治疗子宫内膜异位症(EMT)效果及对患者性激素、抗缪勒管激素(AMH)和妊娠的影响。方法:选取2020年1月-2021年1月本院就诊的EMT患者104例,区组随机化法分为观察组和对照组各52例,两组均行腹腔镜术,术后采用诺雷德治疗,观察组联合激素替代疗法,两组均持续治疗6个月。比较两组治疗效果,于治疗前、治疗6个月后对比两组患者血清性激素[卵泡刺激泡素(FSH)、雌二醇(E_(2))、黄体生成素(LH)]水平、AMH水平、卵巢储备功能(卵巢体积、卵泡窦泡数),治疗后随访1年,比较两组妊娠率和疾病复发率。结果:治疗6个月后,观察组治疗有效率(96.2%)高于对照组(82.7%),两组FSH、E_(2)、LH、卵巢体积均降低且观察组低于对照组,两组卵泡窦泡数、AMH水平均升高且观察组(8.48±0.87个、3.36±0.79 ng/ml)高于对照组(6.89±0.79个、2.68±0.65 ng/ml);随访期间观察组妊娠率(61.5%)高于对照组(42.3%),疾病复发率(3.8%)低于对照组(11.5%)(均P<0.05)。结论:诺雷德联合激素替代疗法治疗EMT疗效提高,能有效降低患者性激素水平,改善患者卵巢储备功和预后。Objective:To explore the effect of zoladex combined with hormone replacement therapy for treating patients with endometriosis(EMT)and its influence on the levels of estrogen and anti-Mullerian hormone(AMH)and the preg-nancy of the patients.Methods:104 patients with EMT who had been undergone laparoscopy in the hospital were se-lected and were divided into two groups(52 cases in each group)by the block randomization method from January 2020 to January 2021.The patients in the observation group were treated by zoladex combined with hormone replacement therapy for 6 months after surgery,and the patients in the control group were treated by zoladex only for 6 months after surgery.The therapeutic effect of the patients,and the levels of serum sex hormones,such as ollicle-stimulating hormone(FSH),estradiol(E2),luteinizing hormone(LH),and AMH,and the ovarian reserve function,such as ovarian volume and antral follicle count,of the patients before treatment and in 6 months after treatment were compared between the two groups.The pregnancy rate and the recurrence rate of EMT of the patients within 1 year of follow-up after treatment were compared between the two groups.Results:The effective rate(96.2%)of the patients in the observation group after 6 months of treatment was significantly higher than that(82.7%)of the patients in the control group.The levels of FSH,E,and LH,and the ovarian volume of the patients in the two groups after 6 months of treatment had decreased significantly,and which of the patients in the observation group were significantly lower than those of the patients in the control group.The antral fllicle count and the AMH level of the patients in the two groups had increased significantly,and which(8.48±0.87 and 3.36±0.79 ng/ml)of the patients in the observation group were significantly higher than those(6.89±0.79 and 2.68±0.65 ng/ml)of the patients in the control group.The pregnancy rate(61.5%)of the patients in the observation group during the follow-up period was significantly higher than that(42.

关 键 词：子宫内膜异位症 激素替代疗法 诺雷德 抗缪勒管激素 卵巢功能 复发 妊娠 

分 类 号：R711.71[医药卫生—妇产科学]