妊娠期高血压疾病患者血清SOCS-3、Lp-PLA2表达及临床意义  

Expression and clinical significance of serum negative regulator of cytokine signal transduction-3 and lipoprotein associated phospholipase A2 of pregnant women with hypertensive disorder complicating pregnancy

作　　者：程骞 王玉慧 刘国力 CHENG Qian;WANG Yuhui;LIU Guoli(Qingdao Hospital,University of Health and Rehabilitation Sciences(Qingdao Municipal Hospital),Shandong Province,266000)

机构地区：[1]康复大学青岛医院,青岛市市立医院,266000

出　　处：《中国计划生育学杂志》2023年第11期2708-2711,共4页Chinese Journal of Family Planning

摘　　要：目的:探讨血清细胞因子信号传导负调控因子(SOCS-3)、脂蛋白相关磷脂酶(Lp-PLA2)在妊娠期高血压疾病(HDCP)中的表达及临床意义。方法:选择2020年8月-2023年1月本院收治的HDCP患者120例,其中HDCP组68例、轻度子痫前期31例(轻度PE组)、重度子痫前期21例(重度PE组),健康孕妇80例为对照组,比较各组及HDCP不同预后患者血清SOCS-3、Lp-PLA2水平,分析HDCP患者血清SOCS-3与Lp-PLA2的相关性及与预后关系。结果:血清SOCS-3、Lp-PLA2重度PE组(0.17±0.02ng/L、36.64±3.79μmol/ml),轻度PE组(0.33±0.06ng/L、23.39±4.28μmol/ml),HDCP组(0.45±0.08ng/L、19.68±2.09μmol/ml),对照组(0.53±0.05ng/L、15.00±1.57μmol/ml)存在差异;HDCP患者中,终止妊娠患者血清SOCS-3(0.29±0.12ng/L)低于正常分娩患者(0.42±0.09ng/L),Lp-PLA2(27.87±8.60μmol/ml)高于正常分娩患者(20.67±3.16μmol/ml)(均P<0.05)。经Spearman相关性分析,血清SOCS-3与Lp-PLA2呈负相关(r=-0.837,P<0.05),且血清SOCS-3与不良预后呈正相关(r=0.536,P<0.05),Lp-PLA2与不良预后呈负相关(r=-0.511,P<0.05)。结论:随着HDCP病情加重,患者血清SOCS-3降低、Lp-PLA2升高,且影响患者预后,两者共同参与了HDCP发生发展,临床应予以密切关注。Objective:To study the expression and clinical significance of serum negative regulator of cytokine signal transduction-3(SOCS-3)and lipoprotein associated phospholipase A2(Lp-PLA2)of pregnant women with hypertensive disorder complicating pregnancy(HDCP).Methods:120 pregnant women with HDCP were selected in study group,including 68 women with HDCP in group A,31 women with mild preeclampsia in group B,and 21 women with severe preeclampsia in group C from August 2020 to January 2023.80 healthy pregnant women were selected in control group during the same period.The serum SOCS-3 and Lp-PLA2 levels of the women were compared among these groups.The correlation between the serum SOCS-3 level of the women in the study group and their serum Lp-PLA2 level and prognosis was analyzed.Results:There were significant differences in the levels of serum SOCS-3 of Lp-PLA2C among the women in group C(0.17±0.02ng/L and 36.64±3.79μmol/ml),in group B(0.33±0.06ng/L and 23.39±4.28μmol/ml),in group A(0.45±0.08ng/L and 19.68±2.09μmol/ml),and in the control group(0.53±0.05ng/L and 15.00±1.57μmol/ml).In the study group,the serum SOCS-3 level(0.29±0.12ng/L)of the women with termination of pregnancy was significantly lower than that(0.42±0.09ng/L)of the women with normal delivery,and the serum Lp-PLA2(27.87±8.60μmol/ml)of the women with termination of pregnancy was significantly higher than that(20.67±3.16μmol/ml)of the women with normal delivery(all P<0.05).Spearman correlation analysis showed hat the tserum SOCS-3level of the women was negatively correlated with their Lp-PLA2level(r=-0.837,P<0.05),and the serum SOCS-3level of the women was positively correlated with their poor prognosis(r=0.536,P<0.05),and the Lp-PLA2level was negatively correlated with their poor prognosis(r=-0.511,P<0.05).Conclusion:With the HDCP aggravation of the pregnant women,their serum SOCS-3level decreases and their Lp-PLA2level increases,both of them can affect the prognosis of the women and are involved in the occurrence and development of thei

关 键 词：妊娠期高血压疾病 子痫前期 细胞因子信号传导负调控因子 脂蛋白相关磷脂酶 预后 相关性 

分 类 号：R714.246[医药卫生—妇产科学]