米索前列醇与控释地诺前列酮阴道栓对过期妊娠产程的影响  

The Effect of Misoprostol and controlled-release Dinoprostone vaginal Suppositories on the Delivery Process of expired Pregnancy

作　　者：刘双艳 牛夏青 LIU Shuangyan;NIU Xiaqing(Department of Obstetrics and Gynecology,Yanling County Maternal and Child Health Hospital,Xuchang Henan 461200,China)

机构地区：[1]鄢陵县妇幼保健院妇产科,河南许昌461200

出　　处：《临床研究》2023年第12期63-66,共4页Clinical Research

摘　　要：目的探讨米索前列醇与控释地诺前列酮阴道栓对过期妊娠产程的影响。方法选择2019年2月至2021年12月许昌市鄢陵县妇幼保健院收治的过期妊娠患者82例,依据抽签法分为观察组与对照组,各41例。对照组给予米索前列醇治疗,观察组给予控释地诺前列酮阴道栓治疗。对比组间引产相关指标(用药至分娩时间、产程时间、分娩过程中出血量)、分娩方式、临床疗效及不良母婴结局,同时对比组间不同时间的宫颈成熟度(Bishop)评分。结果观察组用药至分娩时间[(28.94±3.16)h]、产程时间[(28.94±3.16)h]短于对照组用药至分娩时间[(28.94±3.16)h]、产程时间[(18.96±2.19)h],分娩过程中出血量[(28.67±3.64)mL]少于对照组分娩过程中出血量[(40.58±3.75)mL],差异有统计学意义(P<0.05);观察组引产成功率(95.12%)及阴道分娩率(82.93%)均高于对照组(73.17%、60.98%),差异有统计学意义(P<0.05);治疗前,两组Bishop评分对比,差异无统计学意义(P>0.05);两组治疗后12 h、24 h、48 h的Bishop评分均高于治疗前,且观察组各时点Bishop评分高于对照组,差异有统计学意义(P<0.05);观察组治疗有效率(95.12%)高于对照组(73.17%),差异有统计学意义(P<0.05);观察组不良母婴结局发生率(7.32%)与对照组(19.51%)相比,差异无统计学意义(P>0.05)。结论控释地诺前列通阴道栓治疗过期妊娠的临床疗效优于米索前列醇,可有效缩短用药至分娩时间与产程,减少分娩过程中出血量,促进宫颈成熟,提高引产成功率及阴道分娩率,且具有一定的安全性。Objective To investigate the effects of misoprostol and controlled-release dinoprostone vaginal suppositories on the delivery process of expired pregnancy.Methods A total of 82 expired pregnancy patients admitted to Yanling County Maternal and Child Health Hospital in Xuchang City from February 2019 to December 2021 were selected and divided into observation group and control group based on the method of drawing lots,with 41 cases in each group.The control group was treated with misoprostol,while the observation group was treated with controlled-release dinoprostone vaginal suppositories.The relevant indicators of induced abortion between groups(medication to delivery time,labor process time,bleeding amount during delivery),delivery method,clinical efficacy,and adverse maternal and infant outcomes were compared.At the same time,the cervical maturity(Bishop)scores at different times between groups were compared.Results The observation group's medication to delivery time[(28.94±3.16)h]and labor process time[(28.94±3.16)h]were shorter than the control group's medication to delivery time[(28.94±3.16)h]and labor process time[(18.96±2.19)h].The amount of bleeding during delivery[(28.67±3.64)mL]was less than the control group's bleeding during delivery[(40.58±3.75)mL],and the difference was statistically significant(P<0.05);The success rate of induced abortion(95.12%)and vaginal delivery rate(82.93%)in the observation group were higher than those in the control group(73.17%,60.98%),with statistically significant differences(P<0.05);Before treatment,there was no statistically significant difference in Bishop scores between the two groups(P>0.05);The Bishop scores of the two groups at 12,24,and 48 hours after treatment were higher than those before treatment,and the Bishop scores of the observation group were higher than those of the control group at all time points,with a statistically significant difference(P<0.05);The effective rate of treatment in the observation group(95.12%)was higher than that in the control

关 键 词：过期妊娠 控释地诺前列酮阴道栓 米索前列醇 宫颈成熟 产程 

分 类 号：R714.1[医药卫生—妇产科学]