阿法骨化醇联合甲泼尼龙对过敏性紫癜患儿肾功能及免疫功能的影响研究  

The effect of alpha-calciferol combined with methylprednisolone on renal and immune function in children with allergic purpura

作　　者：王彦芳[1] 史香芬[1] 陈娟娟[1] WANG Yanfang;SHI Xiangfen;CHEN Juanjuan(Department of Pharmacy,The First Affiliated Hospital of Zhengzhou University,Zhengzhou Henan 450000,China)

机构地区：[1]郑州大学第一附属医院药学部,河南郑州450000

出　　处：《临床研究》2023年第12期101-104,共4页Clinical Research

摘　　要：目的探究过敏性紫癜患儿予以阿法骨化醇联合甲泼尼龙治疗对其肾功能改善及T细胞亚群的影响。方法将2021年6月至2023年6月郑州大学第一附属医院收治的120例过敏性紫癜患儿作为研究对象。使用随机数字表法将上述患儿分为研究组和对照组,两组各60例。对照组患儿接受甲泼尼龙治疗,研究组患儿接受阿法骨化醇联合甲泼尼龙治疗,治疗周期均为10 d。观察两组患儿的治疗效果,临床症状(腹部绞痛、消化道出血、皮疹紫癜、关节肿痛)消退时间,治疗前后肾功能改善情况[半胱氨酸蛋白酶抑制剂-C(Cys C)、血肌酐(Scr)、尿素氮(BUN)水平],T细胞亚群(CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+))水平及治疗期间不良反应(头晕乏力、发热、恶心呕吐)发生情况。结果研究组患儿治疗有效率高于对照组,差异有统计学意义(P<0.05);研究组患儿腹部绞痛、消化道出血、皮疹紫癜、关节肿痛消退时间早于对照组,差异有统计学意义(P<0.05);治疗后,研究组患儿Cys C、Scr、BUN水平均低于对照组,差异有统计学意义(P<0.05);研究组患儿CD4^(+)、CD4^(+)/CD8^(+)水平均高于对照组,CD8^(+)水平低于对照组,差异有统计学意义(P<0.05);两组患儿治疗期间不良反应发生率,差异无统计学意义(P>0.05)。结论阿法骨化醇联合甲泼尼龙治疗过敏性紫癜患儿的效果显著,能够加快临床症状消退速度,改善患儿肾功能和免疫功能。Objective To explore the effects of alfacalcidol combined with methylprednisolone treatment on renal function improvement and T cell subsets in children with allergic purpura.Methods 120 children with allergic purpura admitted to The First Affiliated Hospital of Zhengzhou University from June 2021 to June 2023 were selected as the research subjects.The children were divided into a study group and a control group,each with 60 cases,using a random number table method.The control group received methylprednisolone treatment,while the study group received alfacalcidol combined with methylprednisolone treatment,both for a treatment period of 10 days.The treatment effects,clinical symptom(abdominal colic,gastrointestinal bleeding,rash purpura,joint swelling and pain)remission time,renal function improvement[Cystatin C(Cys C),Serum Creatinine(Scr),Blood Urea Nitrogen(BUN)levels],T cell subsets(CD4^(+),CD8^(+),CD4^(+)/CD8^(+))levels,and adverse reactions(dizziness,fatigue,fever,nausea,vomiting)during treatment were observed in both groups.Results The effective rate of treatment in the study group was higher than that in the control group,with a statistically significant difference(P<0.05);the remission time of abdominal colic,gastrointestinal bleeding,rash purpura,and joint swelling and pain in the study group was earlier than that in the control group,with a statistically significant difference(P<0.05);after treatment,the levels of Cys C,Scr,and BUN in the study group were all lower than those in the control group,with a statistically significant difference(P<0.05);the levels of CD4^(+)and CD4^(+)/CD8^(+)in the study group were higher than those in the control group,and the level of CD8^(+)was lower than that in the control group,with a statistically significant difference(P<0.05);there was no statistically significant difference in the incidence of adverse reactions during treatment between the two groups(P>0.05).Conclusion The effect of alfacalcidol combined with methylprednisolone in the treatment of children with all

关 键 词：过敏性紫癜 阿法骨化醇 甲泼尼龙 肾功能 T细胞亚群 

分 类 号：R554.6[医药卫生—血液循环系统疾病]