南阳市卧龙区2019年至2020年新生儿先天性甲状腺功能低下症筛查结果分析  

Analysis of Screening Results of Congenital Hypothyroidism in Newborns in Wolong District,Nanyang City,2019-2020

作　　者：袁非 YUAN Fei(Civil Life Office,Wolong District Maternal and Child Health Hospital,Nanyang Henan 473000,China)

机构地区：[1]南阳市卧龙区妇幼保健院民生办公室,河南南阳473000

出　　处：《临床研究》2023年第12期196-198,共3页Clinical Research

摘　　要：目的分析南阳市卧龙区2019年至2020年新生儿先天性甲状腺功能低下症(CH)筛查结果,为本区残疾儿童的筛查提供科学依据。方法回顾性分析2019年至2020年南阳市卧龙区各机构出生的8670名新生儿检测资料,新生儿均接受足跟滤纸血片采集,采集血片以时间分辨荧光免疫分析法检测甲状腺激素(TSH)对新生儿CH进行筛查,初筛阳性者召回复查,并以血清标本确诊。依据CH筛查结果分为CH组及非CH组,对比两组新生儿出生体重、产妇年龄、分娩孕周、胎数、产妇孕期甲状腺疾病率、产妇孕期食海产品率、家族甲状腺病遗传史、产妇孕期焦虑发生率、产妇不良用药发生率。结果筛查8670名新生儿中,共检出CH新生儿29例;其中2019年19例,2020年10例,发病率为0.33%。CH组及非CH组新生儿分娩孕周、胎数对比,差异无统计学意义(P>0.05),CH组新生儿出生体重显著低于非CH组,CH组新生儿产妇年龄、产妇孕期甲状腺疾病率、产妇孕期食海产品率、家族甲状腺病遗传史、产妇孕期焦虑发生率、产妇不良用药发生率均显著高于非CH组,差异有统计学意义(P<0.05),提示出生体重低、产妇年龄≥35岁、产妇孕期患者甲状腺疾病、产妇孕期食用海产品、有家族甲状腺病遗传史、产妇孕期发生焦虑、产妇孕期存在不良用药均是引发CH发生的重要危险因素,将上述对比差异显著的因素进行多因素非条件Logistic回归分析,结果显示,新生儿出生体重低、产妇年龄≥35岁、妊娠期合并甲状腺疾病、产妇孕期食海产品、产妇甲状腺疾病遗传史、不良用药史为新生儿CH高危因素。结论南阳市卧龙区2019年至2020年新生儿先天性甲状腺功能低下症发生率处于下降趋势,加强孕期筛查与孕产妇孕期、围产期保健尤为重要。Objective To analyze the screening results of congenital hypothyroidism(CH)in newborns from 2019 to 2020 in Wolong District,Nanyang City,and to provide a scientific basis for screening children with disabilities in our district.Methods Retrospective analysis of the test data of 8670 newborns born in various institutions in Wolong District,Nanyang City,from 2019 to 2020.Newborns received heel filter paper blood slides,and blood slides were collected for screening of CH in newborns by time-resolved fluorescence immunoassay for thyroid hormone(TSH),and those with positive initial screening were recalled for retesting,and the diagnosis was confirmed by serum specimens.Based on the results of CH screening,the newborns were divided into CH and non-CH groups,and the two groups were compared in terms of birth weight,maternal age,week of delivery,number of pregnancies,maternal thyroid disease rate during pregnancy,maternal seafood consumption rate during pregnancy,family history of thyroid disease,maternal anxiety rate during pregnancy,and maternal adverse drug use rate.Results Among the 8670 newborns screened,29 newborns with CH were detected,including 19 cases in 2019 and 10 cases in 2020,with a prevalence rate of 0.33%;there was no significant difference in the week of gestation and number of births between the CH and non-CH groups(P>0.05),And the birth weight of newborns in the CH group was significantly lower than that of the non-CH group,the rates of maternal age,maternal thyroid disease during pregnancy,maternal consumption of seafood during pregnancy,family history of thyroid disease,maternal anxiety during pregnancy,and maternal adverse drug use were all significantly higher in the CH group than in the non-CH group,and the comparison between the two groups was statistically significant(P<0.05),suggesting that low birth weight,maternal age≥35 years,maternal thyroid disease during pregnancy,maternal consumption of seafood during pregnancy,family history of thyroid disease,maternal anxiety during pregnancy,and mat

关 键 词：南阳卧龙区 新生儿 先天性甲状腺功能低下症 筛查 

分 类 号：R174.6[医药卫生—妇幼卫生保健]