不同浓度康复新液治疗经皮冠状动脉介入手术术后患者抗血小板治疗后消化道出血的疗效观察  

Clinical Efficacy of Kangfuxin Solution with Different Concentrations in Treatment of Gastrointestinal Bleeding of Patients with Antiplatelet Therapy after PCI

作　　者：王永翠 赵太云[1] 梁海[2] WANG Yong-cui;ZHAO Tai-yun;LIANG Hai(Department of Gastroenterology,Bozhou People′s Hospital,Bozhou Anhui 236800;Pharmacy Department,Bozhou People′s Hospital,Bozhou Anhui 236800)

机构地区：[1]亳州市人民医院消化内科,安徽亳州236800 [2]亳州市人民医院药剂科,安徽亳州236800

出　　处：《世界中西医结合杂志》2023年第10期2027-2032,共6页World Journal of Integrated Traditional and Western Medicine

基　　金：2022年安徽省重点研究与开发计划项目(2022e07020066)。

摘　　要：目的探讨不同浓度康复新液治疗经皮冠状动脉介入手术(Percutaneous coronary intervention,PCI)术后患者抗血小板治疗后消化道出血的临床疗效。方法选取2020年1月—2022年10月期间于亳州市人民医院就诊的PCI术后抗血小板治疗后消化道出血患者96例为研究对象,按随机数字表法分为非康复新液组(0组)、50%浓度康复新液组(50%组)、75%浓度康复新液组(75%组)和100%浓度康复新液组(100%组),每组各24例。4组患者均给予西医对症治疗,治疗周期均为2周。观察比较4组患者止血时间、再出血率、住院时间、安全性评价,治疗前后血常规指标(血红蛋白水平、红细胞计数、红细胞压积)、血凝指标[凝血酶原时间(Prothrombin time,PT)、活化部分凝血活酶时间(Activated partial thromboplastin time,APTT)、D-二聚体(D-dimer,D-D)]及血栓弹力[反应时间(R),凝固角(α),最大振幅(MA)]。结果治疗后4组患者血红蛋白、红细胞计数、红细胞压积水平均较治疗前升高,差异有统计学意义(P<0.05);50%组、75%组、100%组血红蛋白、红细胞计数、红细胞压积水平均较0组升高,差异有统计学意义(P<0.05);75%组、100%组血红蛋白、红细胞计数、红细胞压积水平均较50%组升高,差异有统计学意义(P<0.05);100%组血红蛋白、红细胞计数、红细胞压积水平与75%组比较,差异无统计学意义(P>0.05)。治疗后4组患者血凝指标PT、APTT、D-D水平均较治疗前降低,差异有统计学意义(P<0.05);50%组、75%组、100%组PT、APTT、D-D水平均较0组降低,差异有统计学意义(P<0.05);75%组、100%组PT、APTT、D-D水平均较50%组降低,差异有统计学意义(P<0.05);100%组PT、APTT、D-D水平与75%组比较,差异无统计学意义(P>0.05)。治疗后50%组、75%组、100%组止血时间、住院治疗时间均较0组降低,差异有统计学意义(P<0.05);75%组、100%组止血时间、住院治疗时间均较50%组降低,差异有统计学意义(P<0.05);100%Objective To investigate the clinical efficacy of Kangfuxin Solution with different concentrations in the treatment of gastrointestinal bleeding of patients with antiplatelet therapy after percutaneous coronary intervention(PCI).Methods Ninety-six patients with gastrointestinal bleeding after antiplatelet therapy of PCI treated in Bozhou People′s Hospital were selected and divided into four groups according to random number table method,namely non-Kangfuxin Solution group(0%group),50%Kangfuxin Solution group(50%group),75%Kangfuxin Solution group(75%group),and 100%Kangfuxin Solution group(100%group),with 24 patients in each group.At the same time,the four groups were given symptomatic treatment of Western medicine for two weeks.Blood routine indexes(hemoglobin level,red blood cell count,and hematocrit),blood coagulation indexes[prothrombin time(PT),activated partial thrombin time(APTT),and D-dimer(D-D)level],thrombus elasticity[reaction time(R),solidification angle(α),and maximum am⁃plitude(MA)],hemostasis time,rebleeding rate,hospitalization time,and safety evaluation were observed in the four groups before and after treatment.Results After treatment,the hemoglobin,red blood cell count,and hematocrit of the four groups were higher than those before treatment,and the differences were statistically significant(P<0.05).The hemo⁃globin,red blood cell count,and hematocrit of the 50%group,75%group,and 100%group were higher than those of the 0%group(P<0.05).The hemoglobin,red blood cell count,and hematocrit of the 75%group and 100%group were high⁃er than those of the 50%group(P<0.05).There were no significant differences in hemoglobin,red blood cell count,and hematocrit levels between the 100%group and the 75%group(P>0.05).After treatment,the levels of PT,APTT,and D-D in the four groups were lower than those before treatment(P<0.05),and those in 50%group,75%group,and 100%group were lower than those in 0%group(P<0.05).The levels of PT,APTT,and D-D in the 75%group and the 100%group were lower than those in the 50

关 键 词：康复新液 冠状动脉支架植入术后 抗血小板治疗 消化道出血 血凝指标 

分 类 号：R541.4[医药卫生—心血管疾病]