美托洛尔、厄贝沙坦氢氯噻嗪在老年心力衰竭内科治疗中的价值研究  

Study on the value of metoprolol combined with irbesartan and hydrochlorothiazide in the medical treatment of senile heart failure

作　　者：杨琼 YANG Qiong(Guizhou Electric Power Hospital,Guizhou 550001,China)

机构地区：[1]贵州电力医院,550001

出　　处：《中国实用医药》2023年第21期98-101,共4页China Practical Medicine

摘　　要：目的分析老年心力衰竭患者应用厄贝沙坦氢氯噻嗪及美托洛尔联合治疗的价值。方法选取92例老年心力衰竭患者为研究对象,采取随机数字表法分为观察组和对照组,每组46例。两组患者均接受抗心力衰竭治疗,在此基础上,对照组患者应用美托洛尔治疗,观察组患者在对照组基础上联合厄贝沙坦氢氯噻嗪治疗。对比两组患者治疗前后超声心动图指标、实验室指标及生活质量评分。结果治疗前,两组患者左心室射血分数(LVEF)、每搏输出量(SV)、心排血量(CO)、左心室收缩末期容积(LVESV)对比,差异无统计学意义(P>0.05)。治疗后,观察组患者LVEF(45.46±3.12)%、SV(53.54±4.32)ml、CO(3.62±0.28)L/min明显高于对照组的(38.20±3.44)%、SV(48.20±4.75)ml、CO(3.08±0.34)L/min,LVESV(108.27±7.67)ml低于对照组的(121.21±8.20)ml,差异有统计学意义(P<0.05)。治疗前,两组患者B型脑钠肽(BNP)水平对比,差异无统计学意义(P>0.05)。治疗后,观察组患者BNP水平(709.10±76.50)ng/L明显低于对照组的(880.81±82.32)ng/L,差异有统计学意义(P<0.05)。治疗前,两组患者身体领域、情绪领域、其他领域及综合得分对比,差异无统计学意义(P>0.05)。治疗后,观察组患者身体领域、情绪领域、其他领域及综合得分分别为(25.20±1.77)、(14.24±1.65)、(24.01±2.36)、(62.63±2.87)分,均低于对照组的(29.80±2.43)、(17.68±1.83)、(28.10±2.74)、(74.84±3.04)分,差异有统计学意义(P<0.05)。结论应用厄贝沙坦氢氯噻嗪及美托洛尔联合治疗能够有效改善老年心力衰竭患者心功能及生活质量,值得推广。Objective To analyze the value of metoprolol combined with irbesartan and hydrochlorothiazide in the treatment of senile heart failure.Methods A total of 92 senile patients with heart failure were divided into observation group and control group according to the random numerical table,with 46 cases in each group.Patients in both groups received anti-heart failure treatment,on this basis,patients in the control group were treated with metoprolol,and patients in the observation group were treated with irbesartan and hydrochlorothiazide on the basis of the control group.The echocardiographic indexes,laboratory indexes and quality of life scores of the two groups were compared before and after treatment.Results Before treatment,there was no statistically significant difference in left ventricular ejection fraction(LVEF),stroke volume(SV),cardiac output(CO)and left ventricular end-systolic volume(LVESV)between the two groups(P>0.05).After treatment,the observation group had LVEF of(45.46±3.12)%,SV of(53.54±4.32)ml and CO of(3.62±0.28)L/min,which were significantly higher than those of(38.20±3.44)%,(48.20±4.75)ml and(3.08±0.34)L/min in the control group;LVESV of(108.27±7.67)ml in the observation group was lower than that of(121.21±8.20)ml in the control group;the differences were statistically significant(P<0.05).Before treatment,there was no statistically significant difference in B-type natriuretic peptide(BNP)level between the two groups(P>0.05).After treatment,BNP level of(709.10±76.50)ng/L in the observation group was significantly lower than that of(880.81±82.32)ng/L in the control group,and the difference was statistically significant(P<0.05).Before treatment,there was no statistically significant difference in scores of physical field,emotional field and other field and comprehensive score between the two groups(P>0.05).After treatment,the scores of physical field,emotional field and other field and comprehensive score of the observation group were(25.20±1.77),(14.24±1.65),(24.01±2.36)and(62.63±2.

关 键 词：老年心力衰竭 厄贝沙坦氢氯噻嗪 美托洛尔 心功能 

分 类 号：R541.6[医药卫生—心血管疾病]