早期血液灌流联合碘解磷定注射液治疗急诊有机磷农药中毒的效果及对并发症和生活质量的影响  

Effect of early hemoperfusion combined with pralidoxime iodide injection in the treatment of acute organophosphorus pesticide poisoning and its influence on complications and quality of life

作　　者：丁颖 DING Ying(Department of Internal Medicine,Haijiya Hospital of Danxian County,Heze 274000,China)

机构地区：[1]单县海吉亚医院内科,274000

出　　处：《中国实用医药》2023年第21期120-123,共4页China Practical Medicine

摘　　要：目的分析早期血液灌流联合碘解磷定注射液治疗急诊有机磷农药中毒的效果及对并发症和生活质量的影响。方法140例急诊有机磷农药中毒患者,按随机数字表法分为对照组和研究组,每组70例。两组患者均使用常规治疗,对照组加用碘解磷定注射液行静脉滴注治疗,研究组加用早期血液灌流联合碘解磷定注射液治疗。比较两组患者临床相关指标(阿托品用量、意识恢复时间、胆碱酯酶恢复时间、住院时间),并发症发生情况,生活质量评分。结果研究组阿托品用量(170.53±15.84)ml少于对照组的(321.20±30.11)ml,意识恢复时间(4.97±0.59)d、胆碱酯酶恢复时间(5.02±0.68)d、住院时间(11.35±1.67)d均短于对照组的(9.25±2.10)、(9.87±2.14)、(17.01±2.58)d,差异有统计学意义(P<0.05)。研究组并发症发生率11.43%低于对照组的30.00%,差异有统计学意义(P<0.05)。干预前,两组患者的躯体功能、心理功能、社会功能、物质生活评分比较差异无统计学意义(P>0.05);干预后,两组患者的躯体功能、心理功能、社会功能、物质生活评分均高于干预前,研究组躯体功能评分(89.51±4.28)分、心理功能评分(87.32±5.09)分、社会功能评分(87.21±4.21)分、物质生活评分(88.34±5.14)分均高于对照组的(75.45±2.26)、(71.32±3.11)、(75.16±2.13)、(72.07±3.09)分,差异有统计学意义(P<0.05)。结论有机磷农药中毒患者采用早期血液灌流联合碘解磷定注射液治疗,可缩短意识恢复时间、胆碱酯酶恢复时间及住院时间,减少并发症发生率,能提高生活质量。Objective To analyze the effect of early hemoperfusion combined with pralidoxime iodide injection in the treatment of acute organophosphorus pesticide poisoning and its influence on complications and quality of life.Methods A total of 140 patients with acute organophosphorus pesticide poisoning were divided into control group and study group according to random numerical table,with 70 cases in each group.Patients in both groups were treated with conventional treatment.On this basis,the control group was treated with intravenous infusion of ralidoxime iodide injection,and the study group was treated with early hemoperfusion and ralidoxime iodide injection.The clinical indicators(atropine dosage,consciousness recovery time,cholinesterase recovery time,hospitalization time),complications,and quality of life score were compared between the two groups.Results The atropine dosage of(170.53±15.84)ml in the study group was less than that of(321.20±30.11)ml in the control group;the study group had consciousness recovery time of(4.97±0.59)d,cholinesterase recovery time of(5.02±0.68)d and hospitalization time of(11.35±1.67)d,which were shorter than those of(9.25±2.10),(9.87±2.14)and(17.01±2.58)d in the control group;the differences were statistically significant(P<0.05).The complication rate of 11.43%in the study group was lower than that of 30.00%in the control group,and the difference was statistically significant(P<0.05).Before intervention,there were no statistically significant differences in scores of physical function,psychological function,social function and material life between the two groups(P>0.05).After intervention,the scores of physical function,psychological function,social function and material life in both groups were higher than those before intervention in this group;in the study group,the physical function score was(89.51±4.28)points,the psychological function score was(87.32±5.09)points,the social function score was(87.21±4.21)points and the material life score was(88.34±5.14)points,which

关 键 词：早期血液灌流 碘解磷定注射液 有机磷农药中毒 并发症 

分 类 号：R595.4[医药卫生—内科学]