生长激素促排卵方案用于卵巢低反应患者IVF-ET助孕期间对HCG日E_(2)水平、获卵数及MⅡ卵数的影响  

Effects of growth hormone ovulation induction regimen on estradiol level,number of oocytes and MⅡ oocytes on human chorionic gonadotropin day during in vitro fertilization-embryo transfer assisted pregnancy in patients with poor ovarian response

作　　者：杜平 喻红彪 万飞龙 DU Ping;YU Hongbiao;WAN Feilong(Department of Obstetrics,Nanchong Central Hospital(Nanchong Central Hospital Affiliated to North Sichuan Medical College),Nanchong 637000,Sichuan,China)

机构地区：[1]南充市中心医院(川北医学院附属南充市中心医院)产科,四川南充637000

出　　处：《中国性科学》2023年第10期90-94,共5页Chinese Journal of Human Sexuality

摘　　要：目的 探讨生长激素(GH)促排卵方案用于卵巢低反应(POR)患者体外受精-胚胎移植(IVF-ET)助孕期间对人绒毛膜促性腺激素(HCG)日雌二醇(E_(2))水平、获卵数及MⅡ卵数的影响。方法 选取2019年2月至2022年2月于南充市中心医院接受IVF-ET的120例POR患者作为研究对象,抽签随机分为观察组和对照组,各60例。对照组采用常规促排卵方案,观察组在对照组基础上加用GH。比较两组临床相关指标、HCG日内膜厚度及激素[黄体生成素(LH)、卵泡刺激素(FSH)、E_(2)]水平、周期取消情况及优胚率、妊娠率。结果 观察组获卵总数、正常受精数、MⅡ卵数、胚胎移植数均高于对照组,差异具有统计学意义(P<0.05)。两组HCG日内膜厚度比较,差异无统计学意义(P>0.05)。观察组HCG日E_(2)水平高于对照组,FSH、LH水平低于对照组,差异具有统计学意义(P<0.05)。两组卵子早排、未获卵、无可用胚胎情况比较,差异无统计学意义(P>0.05)。观察组周期取消率(15.00%)显著低于对照组(33.33%),差异具有统计学意义(P<0.05)。两组优胚率与妊娠率比较,差异无统计学意义(P>0.05)。结论 POR患者通过促排卵方案行IVF-ET助孕时添加GH可提高HCG日E_(2)水平,增加获卵数和MⅡ卵数,改善部分IVF-ET结局。Objective To explore the effects of growth hormone(GH)ovulation induction regimen on estradiol(E2)levels,number of oocytes and MⅡoocytes on human chorionic gonadotropin(HCG)day during in vitro fertilization-embryo transfer(IVF-ET)assisted pregnancy in poor ovarian response(POR)patients.Methods A total of 120 patients with POR who received IVF-ET in Nanchong Central Hospital from February 2019 to February 2022 were selected as the study subjects.Patients were randomly divided into observation group and control group,with 60 cases each.The control group was treated with routine ovulation induction protocol,and the observation group was treated with GH based on control group treatment.The clinical related indexes of the two groups,the endometrial thickness,hormone levels[luteinizing hormone(LH),follicle stimulating hormone(FSH),and E2]at HCG day,the cancellation of patients'cycles,the high-quality embryo rate and pregnancy rate between the two groups were compared.Results The total number of eggs obtained,the number of normal fertilization,the number of MⅡeggs and the number of embryo transfer in the observation group were higher than that of the control group,and the difference was significant(P<0.05).There was no statistically significant difference inendometrial thickness between the two groups at HCG day(P>0.05).The E2 level was higher than the control group,and the FSH and LH levels were lower than the control group at HCG day,with statistically significant(P<0.05).The comparison of early eggs,no eggs,and no embryos showed no significant difference(P>0.05).The cycle cancellation rate(15.00%)was significantly lower than that of the control group(33.33%),and the difference was significant(P<0.05).The high-quality embryo rate and the pregnancy rate between the two groups(P>0.05).Conclusions The addition of GH during IVF-ET assisted pregnancy in POR patients through ovulation induction regimen can increase the E2 level at HCG day,increase the number of oocytes and MⅡoocytes,and improve the outcome of some IVF

关 键 词：生长激素 卵巢低反应 体外受精-胚胎移植 人绒毛膜促性腺激素 雌二醇 MⅡ卵数 

分 类 号：R711[医药卫生—妇产科学]