多囊卵巢综合征患者血清神经调节蛋白4、表皮生长因子与胰岛素抵抗的关系  

The relationship between serum neuromodulatory protein 4,epidermal growth factor and insulin resistance in patients with polycystic ovary syndrome

作　　者：王毅 王海娇 崔玉娇 祁麟 何红美[1] WANG Yi;WANG Haijiao;CUI Yujiao;QI Lin;HE Hongmei(Department of Clinical Laboratory,Shijiazhuang Forth Hospital,Shijiazhuang 050400,Hebei,China)

机构地区：[1]石家庄市第四医院检验科,石家庄050400

出　　处：《中国性科学》2023年第11期93-97,共5页Chinese Journal of Human Sexuality

基　　金：石家庄市2020年度河北省医学科学研究重点课题计划(20201381)。

摘　　要：目的 探究多囊卵巢综合征(PCOS)患者血清神经调节蛋白4(NRG4)、表皮生长因子(EGF)水平与胰岛素抵抗(IR)的关系。方法 选取2021年3月至2022年4月石家庄市第四医院诊治的96例PCOS患者作为研究对象,设为PCOS组。根据是否出现胰岛素抵抗分为IR组(n=55)和非IR组(n=41)。选择同期收取的89例健康女性作为对照组。收集所有受试者的年龄、腰臀比(WHR)、体重指数(BMI),采用酶联免疫吸附试验(ELISA)法检测受试者血清NRG4、EGF水平,检测空腹血糖(FPG)、空腹胰岛素(FINS)、甘油三酯(TG)、总胆固醇(TC)、卵泡刺激素(FSH)、黄体生成素(LH)水平,计算稳态模型胰岛β细胞功能指数(HOMA-β)和稳态模型胰岛素抵抗指数(HOMA-IR),采用Pearson分析NRG4、EGF与其他指标的相关性,采用Logistic回归分析PCOS患者出现IR的影响因素。结果 与对照组比较,PCOS组WHR、BMI、NRG4、EGF、FPG、FINS、TG、LH、HOMA-β、HOMA-IR水平均显著升高(P<0.05)。与非IR组比较,IR组WHR、NRG4、EGF、FPG、FINS、LH、HOMA-β、HOMA-IR水平均显著升高(P<0.05)。PCOS患者血清NRG4、EGF水平均与WHR、BMI、FPG、FINS、TG、LH、HOMA-β、HOMA-IR水平呈正相关(P<0.05)。Logistic回归分析显示,WHR、NRG4、EGF是影响PCOS患者IR发生的独立危险因素(P<0.05)。结论 PCOS患者血清NRG4、EGF水平升高,合并IR的PCOS患者NRG4、EGF水平升高更显著,是影响PCOS患者IR发生的独立危险因素。Objective To investigate the relationship between serum levels of neuromodulatory protein 4(NRG4),epidermal growth factor(EGF)and insulin resistance(IR)in patients with polycystic ovary syndrome(PCOS).Methods From March 2021 to April 2022,96 patients with PCOS admitted to Shijiazhuang Forth Hospital were regarded as PCOS group,and they were grouped into IR group(n=55)and non⁃IR group(n=41)according to whether IR occurred.Another 89 healthy women were selected as the control group during the same period.The age,waist hip ratio(WHR)and body mass index(BMI)of all subjects were collected,the levels of serum NRG4 and EGF were detected by enzyme⁃linked immunosorbent assay(ELISA),the fasting blood glucose(FPG),fasting insulin(FINS),triglyceride(TG),total cholesterol(TC),follicle stimulating hormone(FSH)and luteinizing hormone(LH)were measured.The steady⁃state model isletβCell function index(HOMA⁃β)and steady state model insulin resistance index(HOMA⁃IR)were calculated.Pearson analysis was applied to analyze the correlation between NRG4,EGF and biochemical indicators.Logistic regression analysis was used to analyze the influencing factors of IR in PCOS patients.Results Compared with control group,the levels of WHR,BMI,NRG4,EGF,FPG,FINS,TG,LH,HOMA⁃β,and HOMA⁃IR in PCOS group were significantly increased(P<0.05).Compared with non⁃IR group,the levels of WHR,NRG4,EGF,FPG,FINS LH,HOMA⁃β,and HOMA⁃IR in IR group were obviously higher(P<0.05).The levels of serum NRG4 and EGF in PCOS patients were positively correlated with WHR,BMI,FPG,FINS,TG,LH,HOMA⁃β,and HOMA⁃IR levels(P<0.05).Multivariate Logistic regression analysis showed that WHR,NRG4 and EGF were independent risk factors for IR in PCOS patients(P<0.05).Conclusions The levels of serum NRG4 and EGF in patients with PCOS increase,the levels of NRG4 and EGF in PCOS patients with IR are increased more significantly,and they are independent risk factors for IR occurrence in patients with PCOS.

关 键 词：多囊卵巢综合征 神经调节蛋白4 表皮生长因子 胰岛素抵抗 

分 类 号：R711[医药卫生—妇产科学]