不同骨密度水平的糖尿病患者外周血Omentin-1水平、脂代谢、氧化应激的表达及意义  

Expression and significance of omentin-1,lipid metabolism and oxidative stress in peripheral blood of diabetic patients with different BMD levels

作　　者：朱明明[1] 李宗虎 郑宪玲[1] 王颖霞[1] 张树杰[1] 张瑞清[1] ZHU Ming-ming;LI Zong-hu;ZHENG Xian-ling;WANG Ying-xia;ZHANG Shu-jie;ZHANG Rui-qing(The First Department of Endocrinology,Handan Central Hospital,Hebei Province,Handan 56001,China;Department of Physical Examination,Handan Central Hospital,Hebei Province,Handan 56001,China)

机构地区：[1]河北省邯郸市中心医院内分泌一科,河北邯郸056001 [2]河北省邯郸市中心医院健康体检科,河北邯郸056001

出　　处：《河北医科大学学报》2023年第11期1267-1273,共7页Journal of Hebei Medical University

基　　金：河北省医学科学研究课题计划(20210509)。

摘　　要：目的探讨不同骨密度水平的糖尿病患者外周血网膜素1(Omentin-1)水平、脂代谢及氧化应激的表达及意义。方法回顾性纳入收治的2型糖尿病(type 2 diabetes,T2DM)患者120例,根据骨密度水平分为骨量正常组(38例)、骨量减少组(45例)、骨质疏松组(37例),另选取同期体检骨量正常志愿者80例为对照组,测定外周血Omentin-1水平、脂代谢指标[总胆固醇(total cholesterol,TC)、三酰甘油(triglycerides,TG)、高密度脂蛋白胆固醇(high-density lipoprotein cholesterol,HDL-C)、低密度脂蛋白胆固醇(low-density lipoprotein cholesterol,LDL-C)]、氧化应激指标[超氧化物歧化酶(superoxide dismutase,SOD)、丙二醛(malondialdehyde,MDA)、谷胱甘肽过氧化氢酶(glutathione catalase,GSH-Px)]水平。采用Pearson相关分析T2DM患者Omentin-1、脂代谢、氧化应激指标表达相关性,采用有序多分类Logistic回归分析T2DM患者骨代谢状态影响因素。结果Pearson相关分析显示,T2DM患者外周血Omentin-1水平与TC、TG、LDL-C、MDA呈显著负相关(r=-0.407、-0.437、-0.440、-0.460,P<0.01),而T2DM患者外周血Omentin-1水平与HDL-C、SOD、GSH-Px呈显著正相关(r=0.602、0.578、0.650,P<0.01)。不同骨密度亚组T2DM患者性别、年龄、BMI、WHR、FBG、TC、TG、HDL-C、LDL-C水平等比较差异无统计学意义(P>0.05);骨质疏松组、骨量减少组病程、HOMA-IR、MDA水平等均明显高于骨量正常组,且骨质疏松组>骨量减少组(P<0.05);骨质疏松组、骨量减少组SOD、GSH-Px、Omentin-1水平均明显低于骨量正常组,且骨质疏松组<骨量减少组(P<0.05);骨质疏松、骨量减少组糖化血红蛋白(glycosylated hemoglobin,HbA 1c)水平均明显高于骨量正常组(P<0.05),但骨质疏松组与骨量减少组比较差异无统计学意义(P>0.05);骨质疏松组FINS水平明显高于骨量正常组(P<0.05),但与骨量减少组比较差异无统计学意义(P>0.05)。有序多分类Logistic回归分析显示,病程、HOMA-IR为影Objective To explore the expression and significance of peripheral blood omentin-1(Omentin-1)level,lipid metabolism and oxidative stress in peripheral blood of diabetic patients with different bone density levels.Methods A total of 120 patients with type 2 diabetes mellitus(T2DM)admitted were retrospectively included.According to the level of bone mineral density,they were divided into normal bone mass group(n=38),osteopenia group(n=45),and osteoporosis group(n=37),and another 80 physical examinees with normal bone mass during the same period were selected as the control group.The peripheral blood Omentin-1 levels and lipid metabolism indexes[total cholesterol(TC),triglycerides(TG),high-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C)]and oxidative stress indicators[superoxide dismutase(SOD),malondialdehyde(MDA),glutathione catalase(GSH-Px)]levels were measured respectively.Pearson correlation was used to analyze the correlation of Omentin-1,lipid metabolism,and expression of oxidative stress indicators in T2DM patients.Ordered multi-class Logistic regression was used to analyze the influencing factors of bone metabolism in T2DM patients.Results Pearson correlation analysis showed that peripheral blood Omentin-1 levels in T2DM patients were significantly and negatively correlated with TC,TG,LDL-C,and MDA(r=-0.407,-0.437,-0.440,-0.460,P<0.01),while peripheral blood Omentin-1 levels in T2DM patients were significantly and positively correlated with HDL-C,SOD,and GSH-Px(r=0.602,0.578,0.650,P<0.01).There was no difference in gender,age,BMI,WHR,FBG,TC,TG,HDL-C and LDL-C levels in different bone density subgroups of T2DM patients(P>0.05).The course of disease,HOMA-IR and MDA levels in osteoporosis group and osteopenia group were significantly higher than those in normal bone mass group,and higher in osteoporosis group than in the osteopenia group(P<0.05).SOD,GSH-Px,and Omentin-1 levels in osteoporosis group and osteopenia group were significantly lower than those in normal bone mass gro

关 键 词：糖尿病 骨密度 脂代谢 

分 类 号：R587.1[医药卫生—内分泌]