妊娠期糖尿病产妇脐血FTM、AGE水平与新生儿低血糖的相关性研究  

Study on the correlation between umbilical cord blood FTM,AGE levels and neonatal hypoglycemia in pregnant women with gestational diabetes mellitus

作　　者：袁二伟[1] 朱雷 许津莉[1] 郭华贤[1] YUAN Er-wei;ZHU Lei;XU Jin-li;GUO Hua-xian(Department of Neonatology,the First Affiliated Hospital of Hebei North University,Zhangjiakou 075000,China)

机构地区：[1]河北北方学院附属第一医院新生儿科,河北张家口075000

出　　处：《河北医科大学学报》2023年第11期1312-1316,共5页Journal of Hebei Medical University

基　　金：河北省医学科学研究课题计划(20211817)。

摘　　要：目的探讨妊娠期糖尿病产妇脐血果糖胺(fructosamine,FTM)、晚期糖基化终末产物(advanced glycation end products,AGE)水平与新生儿低血糖的相关性。方法选取妊娠期糖尿病产妇94例,根据新生儿有无低血糖分为低血糖组53例和血糖正常组41例。比较2组临床资料、FTM、AGE水平,Pearson相关性分析FTM、AGE水平与空腹血糖和餐后2 h血糖水平的关系,分析新生儿低血糖发生的危险因素,绘制ROC曲线分析FTM、AGE水平对新生儿低血糖的预测价值。结果低血糖组新生儿出生体重低于血糖正常组,早产儿比例、产妇体重指数、空腹血糖、餐后2 h血糖、FTM、AGE水平高于血糖正常组,差异有统计学意义(P<0.05)。Pearson相关性分析结果显示,FTM、AGE水平与空腹血糖和餐后2 h血糖水平均呈正相关(P<0.05)。Logistic回归分析结果显示,FTM、AGE水平过高均为新生儿低血糖发生的危险因素(P<0.05)。FTM、AGE水平联合检测预测新生儿低血糖的AUC值高于单项检测(P<0.05)。结论妊娠期糖尿病产妇脐血FTM、AGE水平过高表达均为新生儿低血糖发生的危险因素,其可有效预测新生儿低血糖发生风险,为临床预防和治疗提供理论参考。Objective To explore the correlation between the levels of fructosamine(FTM),advanced glycation end products(AGE)and neonatal hypoglycemia in pregnant women with gestational diabetes mellitus(GDM).Methods A total of 94 pregnant women with GDM were selected.According to presence of hypoglycemia in the newborns,they were divided into hypoglycemia group(n=53)and normal blood glucose group(n=41).Clinical data,FTM and AGE levels of the two groups were compared.Pearson correlation analysis was conducted to analyze the relationship between FTM and AGE levels with fasting blood glucose(FBG)level and 2 h postprandial blood glucose(2 hPG)level.Risk factors of neonatal hypoglycemia were analyzed,and ROC curve was drawn to analyze the predictive value of FTM and AGE level for neonatal hypoglycemia.Results The birth weight of newborns in the hypoglycemia group was lower than that in the normal blood glucose group,and the proportion of premature infants,maternal body mass index,FBG,2hPG,FTM and AGE levels were higher than those in the normal blood glucose group,with statistical significance(P<0.05).Pearson correlation analysis showed that FTM and AGE levels were positively correlated with FBG and 2 hPG levels(P<0.05).Logistic regression analysis showed that high FTM and AGE level were risk factors for neonatal hypoglycemia(P<0.05).The area under the curve(AUC)value of FTM and AGE levels in combination in predicting neonatal hypoglycemia was higher than that by single factor detection(P<0.05).Conclusion The overexpression of FTM and AGE in cord blood of pregnant women with GDM is a risk factor for neonatal hypoglycemia,which can effectively predict the risk of neonatal hypoglycemia and provide theoretical reference for clinical prevention and treatment.

关 键 词：糖尿病 妊娠 低血糖症 果糖胺 晚期糖基化终末产物 

分 类 号：R714.256[医药卫生—妇产科学]