“聪圣胶囊”对大鼠培养神经细胞的影响  

Effects of Congsheng Capsules on the Rat Cultivated Nerve Cells

作　　者：唐启盛[1] 全胜 黄启福[1] 裴清华[1] 

机构地区：[1]北京中医药大学,北京100029 [2]黑龙江完达山制药厂,黑龙江158306

出　　处：《北京中医药大学学报》2002年第6期18-21,共4页Journal of Beijing University of Traditional Chinese Medicine

基　　金：国家科委"九.五"攻关项目 (No.96 90 6 0 9 0 3 )

摘　　要：观察谷氨酸对神经细胞的毒性作用及用”聪圣胶囊”治疗后对神经细胞产生的效应。用培养大鼠脑神经细胞的方法 ,观察谷氨酸作用于神经细胞后以及用“聪圣胶囊”治疗后 ,神经细胞培养液中的乳酸脱氢酶 (LDH)、丙二醛 (MDA)和细胞内Ca2 +含量变化。结果显示谷氨酸具有神经细胞毒性作用 ;用“聪圣胶囊”治疗 ,减少了LDH漏出和MDA过多产生 ,细胞内Ca2 +明显减少。说明“聪圣胶囊”The toxic effects of glutamic acid on nerve cells and the treating effects of Congsheng Capsules (CC) were investigated. The method of rat cerebral cell culture was used in this experiment. Changes in the levels of LDH and MDA in the nerve cell culture fluid, and the level of Ca 2+ in the nerve cells were observed after glutamic acid and CC were used to the nerve cells respectively. The results showed that glutamic acid had toxic effects on the nerve cells; and CC could reduce the leakage of LDH and the excessive production of MDA, and decrease the level of Ca 2+ . The results suggest that CC have certain protective effects on the nerve cells.

关 键 词：聪圣胶囊 神经细胞 谷氨酸 乳酸脱氢酶 丙二醛 大鼠 培养 

分 类 号：R285.5[医药卫生—中药学]