上皮间充质转化的信号传导在支气管肺发育不良中的研究进展  

Advances in epithelial mesenchymal transition signaling in bronchopulmonary dysplasia

作　　者：林雅婷(综述) 龚小慧(审校)[1] Lin Yating;Gong Xiaohui(Department of Neonatology,Shanghai Children′s Hospital,School of Medicine,Shanghai Jiao Tong University,Shanghai 200062,China)

机构地区：[1]上海交通大学医学院附属儿童医院、上海市儿童医院新生儿科,200062

出　　处：《国际儿科学杂志》2023年第10期667-672,共6页International Journal of Pediatrics

摘　　要：随着围生期医疗技术的迅速发展, 早产儿的存活率明显提高, 但支气管肺发育不良(bronchopulmonary dysplasia, BPD)发病率仍处于高水平。BPD是早产儿常见的慢性呼吸道疾病, BPD早产儿合并其他并发症的发生率和病死率显著增高。目前以肺损伤为特征的"经典BPD"已经转换为"新型BPD", 然而BPD的病理生理机制尚未阐明。近年来, 一些体外和体内实验研究已经证实, 肺泡Ⅱ型上皮细胞能以转化生长因子-β为枢纽, Wnt、SPHK1/S1P等多重信号通路诱导上皮间充质转化从而促进肺纤维化的发生, 为防治BPD提供了新的思路。该文综述EMT中的多种信号传导途径在BPD中的作用机制, 以期为临床治疗BPD提供参考。With the rapid development of perinatal medical technology,the survival rate of preterm infants has increased significantly,but the incidence of bronchopulmonary dysplasia(BPD)is still at a high level.BPD is a common chronic respiratory disease in preterm infants,and the incidence of other complications and death rates of preterm infants with BPD are significantly higher.Currently,the"classic BPD"characterized by lung injury has been converted to"new BPD,"but the pathophysiological mechanism of BPD has not yet been elucidated.In recent years,some experimental studies in vitro and in vivo have demonstrated that alveolar type II epithelial cells can induce epithelial mesenchymal transition(EMT)through multiple signaling pathways,including TGF-βas a hub and Wnt,SPHK1/S1P,etc.,which can promote the development of pulmonary fibrosis,and thus provide a new idea for the prevention and treatment of BPD.This article reviews the mechanisms of multiple signaling pathways in EMT in BPD,in order to give a reference for the clinical treatment of BPD.

关 键 词：支气管肺发育不良 上皮间充质转化 早产儿 肺纤维化 肺泡Ⅱ型上皮细胞 

分 类 号：R722.6[医药卫生—儿科]