涎腺超声评分联合剪切波弹性成像评估干燥综合征疾病活动度的临床价值  

Clinical value of salivary gland ultrasound score combined with shear wave elastography in assessment of disease activity of Sjögren’s syndrome

作　　者：马雅蓉 季阳 王朝歆[1] MAYarong;JI Yang;WANG Zhaoxin(Department of Function,Dongfang Hospital Beijing University of Chinese Medicine,Beijing 100078,China)

机构地区：[1]北京中医药大学东方医院功能科,北京市100078

出　　处：《临床超声医学杂志》2023年第11期864-868,共5页Journal of Clinical Ultrasound in Medicine

基　　金：国家自然科学基金项目(12071458)。

摘　　要：目的探讨涎腺超声(SGUS)评分联合剪切波弹性成像评估干燥综合征(SS)疾病活动度的临床价值。方法选取在我院风湿科门诊或住院部接受诊治的SS患者80例,根据SS疾病活动指数评分将其分为活动组48例及稳定组32例,应用常规超声观察双侧腮腺、颌下腺特征进行SGUS评分;剪切波弹性成像获取双侧腮腺、颌下腺杨氏模量平均值(Emean),比较两组上述参数的差异。绘制受试者工作特征(ROC)曲线分析SGUS评分、腮腺Emean、颌下腺Emean单独及联合评估SS疾病活动度的诊断效能。结果活动组SGUS评分为(2.72±0.80)分,稳定组SGUS评分为(2.13±0.91)分,两组比较差异有统计学意义(P<0.05);活动组腮腺、颌下腺Emean分别为(14.34±2.04)kPa、(9.92±1.29)kPa,稳定组腮腺、颌下腺Emean分别为(12.29±1.51)kPa、(8.85±1.60)kPa,两组比较差异均有统计学意义(均P<0.05)。ROC曲线分析显示,SGUS评分联合两腺体Emean、SGUS评分联合腮腺Emean评估SS疾病活动度的曲线下面积分别为0.828、0.821,均高于SGUS评分联合颌下腺Emean、SGUS评分、腮腺Emean、颌下腺Emean的曲线下面积(0.714、0.668、0.774、0.692),差异均有统计学意义(均P<0.05)。结论SGUS评分联合剪切波弹性成像在评估SS疾病活动度中有一定的临床价值。Objective To explore the clinical value of salivary gland ultrasound(SGUS)score combined with shear wave elastography in assessing the disease activity of Sjögren’s syndrome(SS).Methods Eighty patients with SS who were diagnosed and treated in the clinic or ward of rheumatology department in our hospital were divided into active group(48 cases)and stable group(32 cases)according to the SS disease activity index score.The parotid gland and submandibular gland were observed by routine ultrasound,and SGUS score was obtained according to their characteristics.Average of Young’s modulus(Emean)in both parotid and submandibular glands obtained by shear wave elastography,and the differences of the above parameters between the two groups were compared.Receiver operating characteristics(ROC)curve were drawn to analyze the efficacy of ultrasound score,Emean alone and combined in diagnosing disease activity of SS.Results The SGUS score of the active group and stable group were 2.72±0.80 and 2.13±0.91,with statistical significance(P<0.05).Emean of parotid gland and submandibular gland in active group were(14.34±2.04)kPa and(9.92±1.29)kPa,while those in stable group were(12.29±1.51)kPa and(8.85±1.60)kPa,with statistical significances(both P<0.05).ROC curve analysis showed that the areas under the curve for SGUS scores combined with Emean of both glands and SGUS score combined with parotid gland Emean in assessing disease activity of SS were 0.828,0.821,which were higher than that of SGUS score combined with submandibular gland Emean,SGUS score,parotid gland Emean and submandibular gland Emean alone(0.714,0.668,0.774 and 0.692),with statistical significances(all P<0.05).Conclusion SGUS score combined with shear wave elastography has certain clinical value in assessing disease activity of SS.

关 键 词：超声检查 剪切波弹性成像 干燥综合征 干燥综合征疾病活动指数 超声评分 涎腺 

分 类 号：R445.1[医药卫生—影像医学与核医学] R442.8[医药卫生—诊断学]