过敏性紫癜并发肾损害相关危险因素分析  

Risk factors related to Henoch-Schönlein purpura complicated by renal injury

作　　者：金张思 罗镇 王再兴[1] Jin Zhangsi;Luo Zhen;Wang Zaixing(Department of Dermatovenereology,The First Affiliated Hospital of Anhui Medical University,Hefei 230022,Anhui Province,China)

机构地区：[1]安徽医科大学第一附属医院皮肤性病科,合肥230022

出　　处：《中国基层医药》2023年第11期1689-1692,共4页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的分析过敏性紫癜并发肾损害相关危险因素。方法选取2019年5月至2022年3月安徽医科大学第一附属医院收治的过敏性紫癜患者90例为研究对象,采用回顾性队列研究方法,以是否并发肾损害分为非肾损害组和肾损害组。收集两组的临床资料,采用单因素和多因素logistic回归分析紫癜并发肾损害的相关危险因素。结果两组性别、感染史、腹痛、关节痛、消化道出血及血红蛋白、白蛋白、活化部分凝血活酶、凝血酶原时间、纤维蛋白原、血脂、免疫球蛋白水平差异均无统计学意义(均P>0.05);肾损害组年龄49.5(25,65.25)岁,大于非肾损害组的19(10,30.75)岁(Z=-4.17,P<0.05),既往紫癜发生率为36.2%(21/58),高于非肾损害组的9.4%(3/32)(χ^(2)=7.59,P<0.05),白细胞计数9.66(6.80,14.21)×10^(9)/L,高于非肾损害组的7.78(6.01,10.53)×10^(9)/L(Z=-2.00,P<0.05),血小板计数为222.50(189.75,291.75)×10^(9)/L,低于非肾损害组的274.50(233.00,322.50)×10^(9)/L(Z=-2.71,P<0.05)。logistic回归显示,年龄(OR=1.055,95%CI:1.026~1.084)及既往紫癜(OR=6.610,95%CI:1.653~26.428)为过敏性紫癜并发肾损害的独立危险因素(均P<0.05)。结论过敏性紫癜并发肾损害的发生与患者年龄、既往紫癜、白细胞计数和血小板水平有关。Objective To analyze the risk factors of Henoch-Schonlein purpura complicated by renal injury.Methods Ninety patients with Henoch-Schonlein purpura admitted to The First Affiliated Hospital of Anhui Medical University from May 2019 to March 2022 were included in this study.A retrospective cohort study was conducted,and patients were divided into a non-renal injury group and a renal injury group based on whether they were complicated by renal injury.Clinical data were collected from the two groups.Univariate and multivariate logistic regression analyses were performed to identify the relevant risk factors for Henoch-Schonlein purpura complicated by renal injury.Results There were no significant differences in sex,infection history,abdominal pain,arthralgia,gastrointestinal bleeding,prothrombin time,hemoglobin,albumin,activated partial thromboplastin,fibrinogen,blood lipids,and immunoglobulin levels between the two groups(all P>0.05).The age of patients in the renal injury group was 49.5(25,65.25)years,which was significantly higher than 19(10,30.75)in the non-renal injury group(Z=-4.17,P<0.05).The incidence of previous purpura in the renal injury group was 36.2%(21/58),which was significantly higher than 9.4%(3/32)in the non-renal injury group(χ^(2)=7.59,P<0.05).The white blood cell count in the renal injury group was 9.66(6.80,14.21)×10^(9)/L,which was significantly higher than 7.78(6.01,10.53)×10^(9)/L in the non-renal injury group(Z=-2.00,P<0.05).The platelet count in the renal injury group was 222.50(189.75,291.75)×10^(9)/L,which was significantly lower than 274.50(233.00,322.50)×10^(9)/L in the non-renal injury group(Z=-2.71,P<0.05).Logistic regression analysis showed that age(OR=1.055,95%CI:1.026-1.084)and previous purpura(OR=6.610,95%CI:1.653-26.428)were independent risk factors for Henoch-Schonlein purpura complicated by renal injury(P<0.05).Conclusion The occurrence of Henoch-Schonlein purpura complicated by renal injury is associated with patient age,history of purpura,white blood cell count,and pla

关 键 词：紫癜 过敏性 肾损害 危险因素 

分 类 号：R554.6[医药卫生—血液循环系统疾病] R692[医药卫生—内科学]