PET分子成像在动脉粥样硬化易损斑块中的临床研究进展  

Advances in clinical research on PET molecular imaging in atherosclerotic vulnerable plaques

作　　者：盛洁 张龙江(审校) SHENG Jie;ZHANG Longjiang(Department of Diagnostic Radiology,Affiliated Jinling Hospital,Medical School of Nanjing University/General Hospital of Eastern Theater Command,Nanjing 210002,China)

机构地区：[1]南京大学医学院附属金陵医院/东部战区总医院放射诊断科,南京210002

出　　处：《国际医学放射学杂志》2023年第6期685-690,共6页International Journal of Medical Radiology

摘　　要：动脉粥样硬化(AS)易损斑块破裂易造成严重的不良心脑血管事件。早期诊断易损斑块对降低心血管不良事件尤为重要。正电子发射体层成像(PET)可无创监测AS相关的生物过程,PET示踪剂能够从糖代谢、巨噬细胞病理改变、斑块微环境及AS继发性改变等多方面甄别易损斑块。基于PET的多模态示踪能同时反映AS易损斑块的结构、功能和分子水平变化。就不同PET示踪剂以及基于PET的多模态成像技术在AS易损斑块中的临床应用进展予以综述。The rupture of vulnerable plaques in atherosclerosis(AS)can lead to serious adverse cardiovascular and cerebrovascular events.Early diagnosis of AS is crucial as it can reduce the risk of adverse cardiovascular events.Positron emission tomography(PET)is a non-invasive method to monitor AS-associated biological processes.PET tracers can identify vulnerable plaques from various perspectives,such as glucose metabolism,pathological changes in macrophages,microenvironments,and secondary changes in AS.A PET-based multimodal imaging strategy can simultaneously provide a comprehensive view of the structural,functional,and molecular changes in AS-vulnerable plaques.This review discusses various PET tracers and the latest developments in PET-based multimodal imaging strategies for detecting vulnerable plaques in AS.

关 键 词：动脉粥样硬化 易损斑块 正电子发射体层成像 分子成像 多模态成像 

分 类 号：R817[医药卫生—影像医学与核医学]