探讨经纤维支气管镜灌洗联合吸入性乙酰半胱氨酸溶液对重症肺炎患者血清炎症因子的影响  

Exploring the Effect of Trans-fiberoptic Bronchoscopic Lavage Combined with Inhaled Acetylcysteine Solution on Serum Inflammatory Factors in Patients with Severe Pneumonia

作　　者：韩韬 孙尊鹏[1] HAN Tao;SUN Zunpeng(Department of Critical Care Medicine,Nanjing Jiangning Hospital,Nanjing,Jiangsu Province,211100 China)

机构地区：[1]南京市江宁医院重症医学科,江苏南京211100

出　　处：《系统医学》2023年第16期64-67,共4页Systems Medicine

摘　　要：目的探究经纤维支气管镜灌洗联合吸入性乙酰半胱氨酸溶液对重症肺炎患者血清炎症因子的影响。方法从2019年6月—2023年6月南京市江宁医院收治的重症肺炎患者中随机选择69例作为研究对象,按照随机数表法分为对照组34例、治疗组35例,分别接受经纤维支气管镜灌洗治疗、经纤维支气管镜灌洗联合吸入性乙酰半胱氨酸溶液治疗,观察不同治疗方式对重症肺炎患者血清炎症因子、血气指标的影响。结果两组患者干预前血清炎症因子水平对比,差异无统计学意义(P>0.05);干预7 d后,治疗组C反应蛋白(C-reactive protein,CRP)水平(25.14±6.47)mg/L、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)水平(50.24±6.31)pg/mL、降钙素原(procalcitonin,PCT)水平(0.63±0.24)ng/L均低于对照组,差异有统计学意义(t=2.716,3.160,2.730,P<0.05);干预前,两组患者血气指标对比,差异无统计学意义(P>0.05);干预7 d后,治疗组氧分压(partial pressure of oxygen,PaO_(2))、血氧饱和度(oxygen saturation,SaO_(2))高于对照组,差异有统计学意义(P<0.05);研究组二氧化碳分压(PaCO_(2))低于对照组,差异有统计学意义(P<0.05)。结论重症肺炎患者治疗中,经纤维支气管镜灌洗联合吸入性乙酰半胱氨酸溶液可改善患者血清炎症因子及血气指标,临床应用价值显著。Objective To investigate the effect of trans-fiberoptic bronchoscopic lavage combined with inhaled acetylcysteine solution on serum inflammatory factors in patients with severe pneumonia.Methods A total of 69 patients with severe pneumonia admitted to Nanjing Jiangning Hospital from June 2019 to June 2023 were randomly selected as the study subjects,and were divided into a control group 34 patients and a treatment group 35 patients according to the random number table method,and received trans-fiberoptic bronchoscopic lavage treatment and trans-fiberoptic bronchoscopic lavage combined with inhaled acetylcysteine solution treatment,respectively.Observed the effects of different treatment modalities on serum inflammatory factors and blood gas indexes in patients with severe pneumonia.Results The serum inflammatory factor levels of the two groups of patients before intervention were compared,and the difference was not statistically significant(P>0.05).After 7 d of intervention,the levels of C-reactive protein(CRP)(25.14±6.47)mg/L,tumor necrosis factor-α(TNF-α)(50.24±6.31)pg/ml,and procalcitonin(PCT)(0.63±0.24)ng/L in the treatment group were lower than those in the control group,and the difference was statistically significant(t=2.716,3.160,2.730,P<0.05).Before intervention,the blood gas indexes of the two groups were compared,and the difference was not statistically significant(P>0.05).After 7 d of intervention,partial pressure of oxygen(PaO_(2))and blood oxygen saturation(SaO_(2))were higher in the treatment group than those in the control group,and the difference was statistically significant(P<0.05).Partial pressure of carbon dioxide(PaCO_(2))was lower in the treatment group than that in the control group,and the difference was statistically significant(P<0.05).Conclusion In the treatment of patients with severe pneumonia,trans-fiberoptic bronchoscopic lavage combined with inhaled acetylcysteine solution can improve the patients′serum inflammatory factors and blood gas indexes,and the clinical application

关 键 词：重症肺炎 纤维支气管镜 灌洗 乙酰半胱氨酸溶液 血清炎症因子 血气指标 

分 类 号：R4[医药卫生—临床医学]