布地奈德混悬液、硫酸沙丁胺醇溶液及异丙托溴铵溶液三联雾化吸入治疗肺炎支原体肺炎患儿的效果  

Effect of Triple Aerosol Inhalation of Budesonide Suspension,Salbutamol Sulfate Solution and Ipratropium Bromide Solution on Children with Mycoplasma Pneumoniae Pneumonia

作　　者：何金宁 廖文森 钟景良 HE Jinning;LIAO Wensen;ZHONG Jingliang(Department of Pediatric Internal Medicine,Dongguan Houjie Hospital,Dongguan,Guangdong Province,523945 China)

机构地区：[1]东莞厚街医院儿内科,广东东莞523945

出　　处：《系统医学》2023年第16期145-147,151,共4页Systems Medicine

摘　　要：目的探讨布地奈德混悬液、硫酸沙丁胺醇溶液及异丙托溴铵溶液三联雾化吸入治疗肺炎支原体肺炎患儿的效果。方法选取2020年4月—2022年4月东莞厚街医院收治的肺炎支原体肺炎患儿300例作为研究对象,按照随机数表法分为两组,对照组(150例)、观察组(150例)。两组患儿均给予口服阿奇霉素常规治疗,对照组给予布地奈德联合硫酸沙丁胺醇二联雾化吸入治疗,观察组在对照组的基础上加用异丙托溴铵溶液三联雾化吸入治疗,观察比较两组患儿临床症状消退时间、炎症因子水平及不良反应发生情况。结果观察组临床症状消退时间均较对照组短,差异有统计学意义(P<0.05);治疗后,观察组白细胞介素-4较对照组高,白细胞介素-8水平较对照组低,差异有统计学意义(P<0.05);观察组不良反应发生率为3.33%,低于对照组的9.33%,差异有统计学意义(χ^(2)=4.551,P<0.05)。结论布地奈德混悬液、硫酸沙丁胺醇溶液及异丙托溴铵溶液三联雾化吸入治疗可以显著缩短肺炎支原体肺炎患儿临床症状消退时间,降低炎症因子水平,减少不良反应的发生。Objective To investigate the effect of triple aerosol inhalation of budesonide suspension,salbutamol sulfate solution and ipratropium bromide solution on children with mycoplasma pneumoniae pneumonia.Methods A total of 300 children with mycoplasma pneumoniae pneumonia admitted to Dongguan Houjie Hospital from April 2020 to April 2022 were selected as the study objects and divided into two groups according to random number table method:control group(150 cases)and observation group(150 cases).The children in both groups were given oral azithromycin routine treatment,the control group was given budesonide combined with salbutamol sulfate double atomization inhalation treatment,and the observation group was additionally given triple atomization inhalation therapy with ipratropium bromide solution on the basis of the control group.The time of clinical symptoms resolution,the level of inflammatory factors and the occurrence of adverse reactions were observed and compared between the two groups.Results The time of clinical symptoms in observation group was shorter than that in control group,and the difference was statistically significant(P<0.05).After treatment,the level of interleukin-4 in observation group was higher than that in control group,and the level of interleukin-8 was lower than that in control group,the differences were statistically significant(P<0.05).The incidence of adverse reactions in the observation group 3.33%was lower than that in the control group 9.33%,and the difference was statistically significant(χ^(2)=4.551,P<0.05).Conclusion The triple aerosol inhalation therapy of budesonide suspension,salbutamol sulfate solution and ipratropium bromide solution can significantly shorten the time of clinical symptoms resolution,reduce the level of inflammatory factors and reduce the occurrence of adverse reactions in children with mycoplasma pneumoniae pneumonia.

关 键 词：布地奈德混悬液 硫酸沙丁胺醇溶液 异丙托溴铵溶液 肺炎支原体肺炎 

分 类 号：R4[医药卫生—临床医学]