蝎毒素抗菌肽研究进展及其在动物养殖中的应用前景  

Research Progress of Scorpion Venom Antimicrobial Peptides and Its Application Prospect in Animal Breeding

作　　者：敖日格乐 包智泉 胡和珠拉 胡伊力格其[1,3] Aorigele;BAO Zhiquan;Huhezhula;Huyiligeqi(School of Mongolian Medicine,Inner Mongolia Minzu University,Tongliao 028043,China;Key Laboratory of Quality Control of Traditional Chinese Medicine(Mongolian Medicine),National Medical Products Administration,Tongliao 028043,China;Key Laboratory of Mongolian Medicine Research and Development Engineering of Ministry of Education,Tongliao 028043,China)

机构地区：[1]内蒙古民族大学蒙医药学院,通辽028043 [2]国家药品监督管理局中药(蒙药)质量控制重点实验室,通辽028043 [3]蒙医药研发工程教育部重点实验室,通辽028043

出　　处：《动物营养学报》2023年第11期6810-6829,共20页CHINESE JOURNAL OF ANIMAL NUTRITION

基　　金：国家药品监督管理局中药(蒙药)质量控制重点实验室开放基金项目(MDK2021072);内蒙古自治区自然科学基金项目(2020LH08013);内蒙古民族大学博士科研启动基金(BS598)。

摘　　要：抗菌肽(AMPs)又称抗微生物肽,是自然界中广泛存在且具有生物活性的一类小分子多肽。作为生物体天然免疫系统的重要组成部分,抗菌肽具有广谱抗细菌、抗真菌、抗病毒、抗寄生虫及抗肿瘤细胞等生物活性,并具有独特的抗菌机制、不易使病原生物产生耐药性等特点,可代替抗生素饲料添加剂用于饲养动物病原性疾病的防控。近年来,抗菌肽已在蝎类动物中得到广泛报道,但其应用前景有待深入研究。本文综述了国内外蝎毒素抗菌肽的研究现状、生物活性及其作用机理等,并展望了其在动物养殖中的应用前景。Antibacterial peptides(AMPs),also known as antimicrobial peptides,are a class of small molecular peptides with various biological activities that widely exist in nature.AMPs typically have a broad-spectrum antibacterial activity against pathogens such as bacteria,fungi,viruses,parasites and tumor cells as a key component of the natural innate immune system of organisms.In addition,AMPs as an antibiotic feed additive alternative to prevention and control of pathogenic diseases in raised animals,due to their unique antibacterial mechanisms and no drug resistance.In recent years,AMPs whose application prospects require further research have been widely reported in scorpions.In this article,the research status,biological activity and mechanism of action of scorpion venom AMPs at home and abroad are reviewed,and their application prospects in animal breeding industry are also prospected.

关 键 词：蝎毒素 抗菌肽 生物活性 动物养殖 

分 类 号：S852.2[农业科学—基础兽医学]