基于超临界CO_(2)流体的载药二醋酸纤维释放行为  

Release properties of drug⁃loaded diacetate fiber based on supercritical CO_(2) fluid

作　　者：朱维维 施楣梧 龙家杰[1] ZHU Weiwei;SHI Meiwu;LONG Jiajie(College of Textile and Clothing Engineering,Soochow University,Suzhou,Jiangsu215123,China;Beijing Haidian No.57 Retired Cadres Rest House,Beijing100035,China)

机构地区：[1]苏州大学纺织与服装工程学院,江苏苏州215123 [2]北京海淀第57离职干部休养所,北京100035

出　　处：《纺织学报》2023年第10期31-38,共8页Journal of Textile Research

摘　　要：为获得具有良好缓释性能的生物活性二醋酸纤维,采用超临界CO_(2)流体加工技术,并以具有抗氧化、抗菌功效的生物活性药物白藜芦醇作为模型药物,在不同流体温度及压力条件下制备负载白藜芦醇的二醋酸纤维,考察了不同载药二醋酸纤维在乙醇中的释放曲线,并建立释放模型。结果表明:更高超临界CO_(2)流体温度、压力条件下制备的载药二醋酸纤维在介质中的绝对释放量、绝对释放速率均更高,而累计释放百分比、累计释放速率均更低;释放时间为40或50 min时,释放速率呈现升高现象,释放平衡时药物残留率最高可达50%;白藜芦醇从二醋酸纤维中的释放行为更符合一级释放动力学模型,拟合度R^(2)在0.93以上。Objective Diacetate fiber is endowed with skin care function,distinctly improve its added value.Compared to traditional manufacturing processes,the supercritical CO_(2) fluid technology(SCF-CO_(2))is green,efficient and environmentally friendly since it solubilizes and carries the drug directly to the substrate to fabricate drug-loaded polymer without any solvent residue.In order to achieve the function to nourish skin it is important for the skin care diacetate fiber with good properties to release bioactive drug.Therefore,the influences of supercritical CO_(2) fluid processing conditions on the release property of skin care diacetate fiber were investigated.Method Resveratrol with antioxidant and antibacterial effects was utilized as the model drug.Resveratrol-loaded diacetate fiber was fabricated by SCF-CO_(2) under different temperatures and different pressures.The resveratrol-loaded diacetate fiber was placed in the release medium ethanol to investigate the effects of fluid temperature(70,80,90℃)and pressure(12,16,20 MPa)on the release amount and the release rate of resveratrol from resveratrol-loaded diacetate fiber for the build-up of the release models.Results When the SCF-CO_(2) temperatures were 70,80,90℃respectively,the loading capacity of resveratrol on diacetate fiber were 0.358×10^(-4),0.884×10^(-4),2.78×10^(-4)g/g.It was found that the higher processing temperature of SCF-CO_(2) resulted in the higher loading capacity.The absolute release amount and absolute release rate were increased along with the increasing loading capacity.The cumulative release percentage and the cumulative release rate were decreased when increasing SCF-CO_(2) temperature(Fig.1(c),Fig.1(d)).About 40%resveratrol was remained in diacetate fiber when the release was in equilibrium under 90℃of SCF-CO_(2) temperature.When the releasing time was 40 min a rise for release rate was witnessed under 70,80℃of SCF-CO_(2) temperature(Fig.1(b),Fig.1(d)),but the release rate rise appeared under 90℃of SCF-CO_(2) temperature 50

关 键 词：超临界CO_(2)流体 二醋酸纤维 白藜芦醇 绝对释放量 缓释性能 释放速率 释放模型 

分 类 号：TS195.6[轻工技术与工程—纺织化学与染整工程]