A prospective longitudinal study shows putamen volume is associated with moderate amphetamine use and resultant cognitive impairments  

作　　者：Keith M.Kendrick Joerg Daumann Daniel Wagner Philip Koester Marc Tittgemeyer Qiang Luo Euphrosyne Gouzoulis-Mayfrank Benjamin Becker 

机构地区：[1]The Clinical Hospital of Chengdu Brain Science Institute,Key Laboratory for Neuroinformation,Center for Information in Medicine,School of Life Science and Technology,University of Electronic Science and Technology of China,Chengdu,China [2]Department of Psychiatry and Psychotherapy,University of Cologne,Germany [3]Max-Planck Institute for Neurological Research,Cologne,Germany [4]Institute of Science and Technology for Brain-Inspired Intelligence,Ministry of Education Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence,Fudan University,Shanghai,PR China [5]LVR Clinics of Cologne,Cologne,Germany

出　　处：《Psychoradiology》2021年第1期3-12,共10页精神影像学（英文）

基　　金：supported by the National Key Research and Development Program of China(grant no.2018YFA0701400);Q.L.was supported by the National Key Research and Development Program of China(grant no.2018YFC0910503);National Natural Science Foundation of China(grant no.81873909);Shanghai Municipal Science and Technology Major Project(grant no.2018SHZDZX01);Natural Science Foundation of Shanghai(grant no.20ZR1404900);the Zhangjiang Laboratory.The authors thank all volunteers for their participation in this study.The authors declare that they have no conflict of interest.

摘　　要：Background:Amphetamine-type stimulants(ATS)have become a critical public health issue.Animal models have indicated a clear neurotoxic potential of ATSs.In humans,chronic use has been associated with cogni-tive deficits and structural brain abnormalities.However,cross-sectional retrospective designs in chronic users cannot truly determine the causal direction of the effects.Objective:To prospectively determine effects of occasional ATS use on cognitive functioning and brain structure.Methods:In a prospective longitudinal study design,cognitive functioning and brain structure were assessed at baseline and at 12-month follow-up in occasional ATS users(cumulative lifetime use<10 units at baseline).Results:Examination of change scores between the initial examination and follow-up revealed declined verbal memory performance and putamen volume in users with high relative to low interim ATS exposure.In the entire sample,interim ATS use,memory decline,and putamen volume reductions were strongly associated.Conclusions:The present findings support the hypothesis that ATS use is associated with deficient dorsal stri-atal morphology that might reflect alterations in dopaminergic pathways.More importantly,these findings strongly suggest that even occasional,low-dose ATS use disrupts striatal integrity and cognitive functioning.

关 键 词：AMPHETAMINES brain volume dorsal striatum MDMA PROSPECTIVE STIMULANTS 

分 类 号：Z89[文化科学]